检验医学与临床2024，Vol.21Issue(16)：2334-2339,2344,7.DOI:10.3969/j.issn.1672-9455.2024.16.007
绝经后女性骨质疏松及骨质疏松性骨折的危险因素分析
Analysis of risk factors for osteoporosis and osteoporotic fractures in postmenopausal women
摘要
Abstract
Objective To investigate the risk factors for osteoporosis(OP)and osteoporotic fracture in postmenopausal women.Methods A total of 1 047 postmenopausal women attending Dazhou City Central Hospital from September 2021 to May 2023 were retrospectively selected as the study subjects,who were di-vided into the OP group and the non-OP(NOP)group according to the size of bone mineral density(BMD)measurements,and the patients in the OP group were subdivided into the fracture group and the non-fracture group according to the occurrence of osteoporotic fractures.Multivariate Logistic regression analysis was used to analyze influencing factors for OP or osteoporotic fracture;receiver operating characteristic(ROC)curve was plotted to analyze the diagnostic value of serum homocysteine(HCY)and prealbumin(PA)for OP or os-teoporotic fracture.Results The age,the proportion of patients with a history of hypertension and the levels of Urea and HCY in the OP group were higher than those in the NOP group,whereas the body mass index(BMI),T scores of total hip BMD and lumbar spine BMD,ALT,AST,albumin,PA,Ca2+,total cholesterol and low-density lipoprotein levels were lower than those in the NOP group,and the differences were all statis-tically significant(P＜0.05).The results of multivariate Logistic regression analysis showed that age,elevat-ed serum HCY level and decreased BMI and PA level were risk factors for OP(P＜0.05).The results of ROC curve showed that the area under the curve(AUC)of joint detection of age,BMI,HCY and PA for prediction of OP was 0.743,which was significantly higher than that predicted by the individual indicators alone(P＜0.05).Serum PA level in the fracture group was lower than that in the non-fracture group,whereas HCY level was higher than that in the non-fracture group,and the differences were statistically significant(P＜0.05).The results of multivariate Logistic regression analysis showed that increased serum HCY level and decreased PA level were risk factors for osteoporotic fracture in patients with OP(P＜0.05).The results of ROC curves showed that the AUCs of serum HCY and PA alone and in combination for predicting osteoporotic fracture were 0.725,0.602 and 0.742,respectively.Conclusion According to the changes of serum HCY and PA levels can better predict the occurrence of osteoporotic fracture in postmenopausal women,but the performance in predicting the occurrence of OP is poor,while age and BMI have some value in predicting the occurrence of OP.关键词
骨质疏松/女性/绝经/骨质疏松性骨折/同型半胱氨酸/前清蛋白Key words
osteoporosis/female/postmenopausal/osteoporotic fracture/homocysteine/preal-bumin分类
临床医学引用本文复制引用
唐波,吴敏,孔祥鑫,王枰稀..绝经后女性骨质疏松及骨质疏松性骨折的危险因素分析[J].检验医学与临床,2024,21(16):2334-2339,2344,7.基金项目
2023年四川省科技创新(苗子工程)培育及小发明小创造项目(MZGC20230048) （苗子工程）
四川省医学会2019年四川医学科研课题立项(S19062). （S19062）
