检验医学与临床2024，Vol.21Issue(16)：2340-2344,5.DOI:10.3969/j.issn.1672-9455.2024.16.008
支气管哮喘并发肺部感染患儿血清HDAC1、KLF5水平及意义
Levels and significance of serum HDAC1 and KLF5 in children with bronchial asthma complicated by pulmonary infection
摘要
Abstract
Objective To investigate the levels and predictive values of serum histone deacetylase 1(HDAC1)and Kruppel like factor 5(KLF5)of children with bronchial asthma(BA)complicated with pul-monary infection.Methods A total of 140 children with BA who underwent treatment in Qingdao Municipal Hospital from June 2022 to January 2023 were collected as research subjects and divided into uninfected group(n=79)and infected group(n=61)based on whether they were complicated with pulmonary infection or not;while another 140 healthy individuals who underwent physical examination during the same period in Qingdao Municipal Hospital were selected as control group.The levels of serum HDAC1 and KLF5 in each group were compared;Multivariate Logistic regression analysis was applied to analyze the influencing factors of pulmonary infection in children with BA;Receiver operating characteristic(ROC)curve was applied to ana-lyze the predictive value of serum HDAC1 and KLF5 levels for pulmonary infection in BA children.Results The serum levels of HDAC1 and KLF5 in the infected group were obviously higher than those in the uninfected group and the control group(P＜0.05);the serum levels of HDAC1 and KLF5 in the uninfected group were obviously higher than those in the control group(P＜0.05).The proportion of children with fami-ly history of asthma in the infected group was higher than that in the uninfected group,and the duration of the disease was longer than that in the uninfected group,with statistically significant differences(P＜0.05).Mult-ivariate Logistic regression analysis results showed that serum HDAC1,KLF5 levels,family history of asth-ma,and course of disease were the influencing factors for pulmonary infection in BA children(P＜0.05).ROC curve results showed that the area under the curve of HDAC1 combined with KLF5 for pulmonary infection in BA children was 0.930,which was better than that of single detection of serum HDAC1 and KLF5(Z=3.408,P=0.001;Z=2.539,P=0.011).Conclusion The levels of serum HDAC1 and KLF5 in children with pulmonary infection complicated by BA are obviously increased,and the combined detection of serum HDAC1 and KLF5 has good predictive value for pulmonary infection in children with BA.关键词
组蛋白去乙酰化酶1/Kruppel样因子5/支气管哮喘/肺部感染/儿童Key words
histone deacetylase 1/Kruppel like factor 5/bronchial asthma/pulmonary infection/children分类
医药卫生引用本文复制引用
刘明华,徐金勇,王培培..支气管哮喘并发肺部感染患儿血清HDAC1、KLF5水平及意义[J].检验医学与临床,2024,21(16):2340-2344,5.基金项目
山东省医药卫生科技发展计划项目(202004070709). （202004070709）
