检验医学与临床2024，Vol.21Issue(16)：2351-2356,2361,7.DOI:10.3969/j.issn.1672-9455.2024.16.010
健脾熄风汤治疗脾虚风动型儿童抽动障碍疗效及对血清神经递质、T淋巴细胞亚群水平的影响
Clinical value of Jianpi Xifeng Decoction combined with tiapride tablet in treatment of children with tic disorder and its influence on serum neurotransmitter and T lymphocyte subsets
摘要
Abstract
Objective To investigate the clinical efficacy of Jianpi Xifeng Decoction in the treatment of spleen deficiency and wind-induced tic disorder in children and its influence on the levels of serum neurotrans-mitter and T lymphocyte subsets.Methods Retrospective analysis was performed on 80 children with spleen deficiency and wind-induced tic disorder in Daqing Hospital of Traditional Chinese Medicine from January 2021 to January 2022,who were divided into control group and observation group according to the difference of the treatment programs,with 40 cases in each group.The control group was given tiapride tablets for treat-ment,while the observation group was treated with Jianpi Xifeng Decoction combined with tiapride tablet,and both groups were treated continuously for 8 weeks.The Yale General Tic Severity Scale(YGTSS)scores and clinical efficacy were compared between the two groups.The TCM syndrome scores and serum neurotransmit-ter[dopamine(DA),norepinephrine(NE),5-hydroxytryptamine(5-HT)]and T lymphocyte subsets(CD3+,CD4+,CD4+/CD8+)were compared between the two groups before and after treatment,and the occurrence of the adverse reactions were analyzed between the two group.Results After treatment,the motor tic scores,vo-cal tic scores,social impairment scores and YGTSS total scores of the children in both groups were lower than those before treatment,and which in the observation group were significantly lower than those in the control group,with statistically significant differences(P＜0.05).After treatment,the total effective rate of the obser-vation group was 97.50％,which was significantly higher than 85.00％of the control group(P＜0.05).After treatment,the scores of all Chinese syndromes in the observation group were lower than those in the control group(P＜0.05).The results of repeated-measures ANOVA showed that there were interaction effect,time effect and intergroup effect for DA,NE,CD4+,CD8+levels and CD4+/CD8+ratios in the two groups(P＜0.05),and time effect and intergroup effect for 5-HT and CD3+levels(P＜0.05).Further analysis of individ-ual effects found that CD4+levels and CD4+/CD8+ratios in the observation group on 4th week and 8th week after treatment were higher than those in the control group,while the serum levels of DA,NE,CD8+were lower than those in the control group,with statistically significant differences(P＜0.05).The serum levels of DA,NE,CD8+in both group on 8th week after treatment were lower than those on 4th week after treatment,while the CD4+level and CD4+/CD8+ratio were higher than those on 4th week after treatment,with statisti-cally significant differences(P＜0.05).During treatment,no obvious adverse reactions occurred in both groups.Conclusion Jianpi Xifeng Decoction has clear curative effect on tic disorder of spleen deficiency and wind-induced children,and it can significantly improve the clinical symptoms of children,which may be related to inhibiting the secretion of dopamine and norepinephrine and regulating the immune function of the body.关键词
健脾熄风汤/儿童抽动障碍/脾虚风动证/去甲肾上腺素/多巴胺/T淋巴细胞Key words
Jianpi Xifeng Decoction/tic disorder in children/wind stirring due to spleen deficiency syndrome/noradrenaline/dopamine/T lymphocyte cells分类
医药卫生引用本文复制引用
史霁,徐鑫,徐金星,张万臣,张秋莹,杨雪,朱晶,吴冬梅..健脾熄风汤治疗脾虚风动型儿童抽动障碍疗效及对血清神经递质、T淋巴细胞亚群水平的影响[J].检验医学与临床,2024,21(16):2351-2356,2361,7.基金项目
黑龙江省中医药科研项目(ZHY2020-022). （ZHY2020-022）
