检验医学与临床2024，Vol.21Issue(16)：2357-2361,5.DOI:10.3969/j.issn.1672-9455.2024.16.011
血清FGFR2、Leptin对特发性矮小症患儿的诊断价值及其水平与骨代谢指标的相关性
Diagnostic value of serum serum FGFR2 and Leptin in children with idiopathic dwarfism and correlation of their levels with bone metabolic indices
摘要
Abstract
Objective To explore the correlation between serum levels of fibroblast growth factor receptor 2(FGFR2)and Leptin and bone metabolism indices in children with idiopathic dwarfism,and their diagnostic value.Methods A total of 138 children with idiopathic dwarfism who enrolled in the hospital from September 2021 to September 2023 were collected as observation group,while 141 healthy children who underwent health checkups in the hospital during the same period were selected as the control group.Enzyme-linked immu-nosorbent assay was applied to detect serum levels of FGFR2 and Leptin;the automatic biochemistry analyzer was used to detect the levels of bone metabolism indices,including 25-hydroxyvitamin D,type Ⅰ precollagen amino acid prepeptide(P Ⅰ NP),osteocalcin(OC)and bone-specific alkaline phosphatase(BAP);Pearson cor-relation analysis was applied to examine the correlation between serum FGFR2 and Leptin levels and bone me-tabolism indices levels in children with idiopathic dwarfism;multivariate Logistic regression was applied to an-alyze the factors influencing the development of idiopathic dwarfism;receiver operator characteristic(ROC)curve was plotted to analyze the diagnostic value of serum FGFR2 and Leptin alone and in combination for idi-opathic dwarfism.Results The body mass,height and levels of 25-(OH)D,P Ⅰ NP,OC,BAP,FGFR2 and Leptin in the observation group were obviously lower than those in the control group,and the proportion of sexual development stage Ⅱ-Ⅴ was greatly higher than that in the control group,with statistically significant differences(P＜0.05).Pearson correlation analysis results showed that the serum levels of FGFR2 and Leptin in children with idiopathic dwarfism were positively correlated with 25-(OH)D,P Ⅰ NP,OC,BAP,FGFR2 and Leptin levels(P＜0.05).Multivariate Logistic regression analysis results showed that elevated FGFR2 and Leptin levels were protective factors for the development of idiopathic dwarfism(P＜0.05).ROC curves re-sults showed that the area under the curve for the diagnosis of idiopathic dwarfism by serum FGFR2 and lep-tin alone and in combination was 0.834,0.851 and 0.914,respectively.Conclusion Serum FGFR2 and Leptin levels in children with idiopathic dwarfism are low,and both of them are obviously correlated with bone me-tabolism indices,which might have certain value in the diagnosis of idiopathic dwarfism.关键词
特发性矮小症/儿童/成纤维生长因子受体2/瘦素/骨代谢指标/诊断Key words
idiopathic dwarfism/children/fibroblast growth factor receptor 2/Leptin/bone me-tabolism indices/diagnosis分类
医药卫生引用本文复制引用
李丽欣,付智伟,赵胜侠..血清FGFR2、Leptin对特发性矮小症患儿的诊断价值及其水平与骨代谢指标的相关性[J].检验医学与临床,2024,21(16):2357-2361,5.基金项目
河北省卫生健康委员会指导性科技计划项目(20221656). （20221656）
