检验医学与临床2024，Vol.21Issue(16)：2373-2379,7.DOI:10.3969/j.issn.1672-9455.2024.16.014
PABPC1在肝细胞癌患者癌组织中的表达及其与预后的关系
Expression levels of PABPC1 in hepatocellular carcinoma and its relationship with prognosis
摘要
Abstract
Objective To analyze the expression of polyadenylate-binding protein 1(PABPC1)in cancer tissues of patients with hepatocellular carcinoma(HCC)and its effect on prognosis.Methods PABPC1 mR-NA expression levels in cancer tissues of 369 HCC patients and 50 normal liver tissues were analyzed by data from The Cancer Genome Atlas(TCGA).Retrospective analysis and comparison of PABPC1 mRNA expres-sion levels in cancer tissues and paracancerous normal tissue of 166 HCC patients who attended the hospital from January 2018 to February 2019,and prognosis of HCC patients was conducted,as well as the PABPC1 expression level in cancer tissues of HCC patients with different clinicopathological features.The efficacy of PABPC1 mRNA expression levels to distinguish cancerous tissues from paracancerous tissues was analyzed by plotting receiver operating characteristic(ROC)curve,and factors affecting the prognosis of HCC patients were analyzed by multivariate COX regression analysis auording to the follow-up results.Results The results of TCGA data showed that the PABPC1 mRNA expression level in 369 cancer tissues of HCC patients was significantly higher than that in 50 normal liver tissues(P＜0.05).In clinical case analysis,the PABPC1 mR-NA and PABPC1 protein positive expression rate in cancer tissues of HCC patients were significantly higher than those in paracancerous tissues(P＜0.05),and the PABPC1 mRNA expression level in patients with pos-itive protein expression of PABPC1 was 2.76±0.79,which was significantly higher than 1.52±0.84 in pa-tients with negative expression(P＜0.001).ROC curve result showed that the area under the curve of PAB-PC1 mRNA for distinguishing cancerous tissues from paracancerous tissues was 0.913.The positive expres-sion rates of PABPC1 protein in HCC patients with UICC stage Ⅲ-Ⅳ,lymph node metastasis and multiple tumor foci were higher than those in HCC patients with UICC stage Ⅰ-Ⅱ,no lymph node metastasis and single tumor foci,with statistically significant differences(P＜0.05).During the follow-up period,50 patients(30.12％)died within 1 year after surgery,95 patients(57.23％)died within 3 years after surgery,and 101 patients(60.84％)died within 5 years after surgery;the results of multivariate COX regression analysis showed that the expression of PABPC1 protein in cancerous tissues was an independent factor influencing the survival of patients with HCC at 1 year,3 years and 5 years(P＜0.05).There was a statistically significant difference in 1-year,3-year,and 5-year OS between HCC patients with positive and negative PABPC1 protein expression in cancer tissues(P＜0.001).Conclusion The expressions of PABPC1 mRNA and protein are high in cancer tissues of HCC patients,and the high expression of PABPC1 protein predicts poor survival in HCC patients.关键词
多聚腺苷酸结合蛋白胞质1/肝细胞癌/临床病理特征/预后/总生存期Key words
polyadenylate-binding protein 1/hepatocellular carcinoma/clinicopathological characteris-tics/prognosis/overall survival分类
医药卫生引用本文复制引用
白素琴,张清雯,演何钦,李晓波..PABPC1在肝细胞癌患者癌组织中的表达及其与预后的关系[J].检验医学与临床,2024,21(16):2373-2379,7.基金项目
陕西省科学技术重点研发项目(2019SF-16). （2019SF-16）
