检验医学与临床2024，Vol.21Issue(16)：2380-2384,2389,6.DOI:10.3969/j.issn.1672-9455.2024.16.015
血清KL-6、PTX3、HBP水平与老年重症肺炎合并呼吸衰竭患者预后的相关性
Correlation of serum KL-6,PTX3,HBP and the prognosis of elderly patients with severe pneumonia complicated with respiratory failure
摘要
Abstract
Objective To investigate the correlation of serum Krebs von den Lungen-6(KL-6),pentraxin 3(PTX3),heparin-binding protein(HBP)and the prognosis of elderly patients with severe pneumonia compli-cated with respiratory failure.Methods From December 2021 to May 2023,372 elderly patients with severe pneumonia complicated with respiratory failure enrolled in Department of Intensive Care Medicine of Zhangjia-kou First Hospital were collected as research objects,who were divided into death group and survival group according to the prognosis after 28 days.Enzyme-linked immunosorbent assay was applied to detect serum lev-els of KL-6,PTX3,and HBP.Pearson correlation analysis was applied to analyze the correlation between KL-6,PTX3,HBP levels,white blood cell count(WBC)and levels of C-reactive protein(CRP),procalcitonin(PLT)and acute physiology and chronic health evaluation Ⅱ(APACHE Ⅱ)score.Multivariate Logistic re-gression analysis was applied to analyze the factors affecting prognosis.Receiver operating characteristic(ROC)curve was applied to analyze the predictive value of serum KL-6,PTX3,HBP levels for prognosis of patients with severe pneumonia complicated with respiratory failure.Results After 28 d of follow-up,among 372 patients,312 survived(survival group)and 60 died(death group).The serum levels of KL-6,PTX3 and HBP in the survival group were obviously lower than those in the death group(P＜0.05).The differences in ICU length of stay,duration of mechanical ventilation,neutrophil counts and WBC,PaO2/FiO2,APACHE Ⅱ score and PCT,CRP,interleukin-10 levels were statistically significant between the two groups(P＜0.05).Pearson analysis results showed that serum levels of KL-6,PTX3 and HBP were positively correlated with WBC,APACHE Ⅱ score and PCT,CRP levels(P＜0.05).Multivariate Logistic regression analysis showed that KL-6,PTX3,HBP,WBC,PCT and CRP were the influencing factors of death in elderly patients with se-vere pneumonia complicated with respiratory failure(P＜0.05).The area under the curve(AUC)of KL-6,PTX3 and HBP combined to predict the death of elderly patients with severe pneumonia combined with respir-atory failure was significantly higher than the AUC of each index alone(ZKL-6-combination=4.590,P＜0.001;ZPTX3-combination=3.823,P=0.001;ZHBP-combination=5.471,P＜0.001).Conclusion The serum KL-6,PTX3 and HBP levels in elderly patients with severe pneumonia complicated with respiratory failure are high,which are closely related to the prognosis of patients,and KL-6,PTX3 and HBP have an important role in assessing the prognosis of elderly patients with severe pneumonia combined with respiratory failure.关键词
Ⅱ型肺泡细胞表面抗原/正五聚蛋白3/肝素结合蛋白/老年/重症肺炎/呼吸衰竭/预后Key words
Krebs von den Lungen-6/pentraxin 3/heparin-binding protein/elderly/severe pneu-monia/respiratory failure/prognosis分类
医药卫生引用本文复制引用
宋秉睿,王建洪,史丽娜,李有亮,李欣,岳树春..血清KL-6、PTX3、HBP水平与老年重症肺炎合并呼吸衰竭患者预后的相关性[J].检验医学与临床,2024,21(16):2380-2384,2389,6.基金项目
河北省卫生健康委员会科研基金项目(20221895). （20221895）
