检验医学与临床2024，Vol.21Issue(16)：2385-2389,5.DOI:10.3969/j.issn.1672-9455.2024.16.016
尿MAU联合血清NGAL、IL-27在糖尿病肾病诊断中的应用价值
Application value of urine MAU combined with serum NGAL and IL-27 in the diagnosis of diabetes nephropathy
摘要
Abstract
Objective To explore the application value of urinary microalbumin(MAU)combined with se-rum neutrophil gelatinase-associated lipocalin(NGAL)and interleukin-27(IL-27)in the diagnosis of diabetes nephropathy(DN).Methods From February 2021 to March 2022,50 patients with diabetes mellitus(DM)who admitted to the hospital were selected as the DM group and 55 patients with diabetic nephropathy(DN)as the DN group,while 60 age-matched healthy people who took medical examination in the hospital during the same period were selected as the control group.The serum NGAL,IL-27,hemoglobin,serum albumin,ser-um cystatin C,urinary MAU,urinary creatinine levels and 24 h urinary protein quantity in the three groups were detected.Pearson's correlation was used to analyze the correlation between serum NGAL and IL-27 lev-els and urinary MAU level and 24 h urinary protein quantity in DN patients;the receiver operating characteris-tic(ROC)curve was plotted to analyze the diagnostic value of urinary MAU,serum NGAL and IL-27 alone and in combination for the diagnosis of DN.Results The levels of serum cystatin C,urinary creatinine,urinary MAU,serum NGAL,IL-27 levels,urinary MAU/urinary creatinine ratio and 24 h urinary protein quantity in the DM group and DN group were significantly higher than those in the control group,which in the DN group were higher than those in the DM group,and the differences had staistically significant differences(P＜0.05).The levels of hemoglobin,serum albumin in the DM group and DN group were lower than those in the control group,which in the DN group were lower than those in the DM group,with statistically significant differences(P＜0.05).The results of Pearson correlation analysis showed that the levels of serum NGAL and IL-27 in DN patients were positively correlated with urinary MAU and 24 h urinary protein quantity(P＜0.05).ROC curve analysis results showed that the area under the curve(AUC)of urinary MAU,serum NGAL and IL-27 in diagnosing DN were 0.837,0.842 and 0.847,respectively,and the AUC of the combined detection of the above three indexes in diagnosing DN was 0.940,which was higher than that of single detec-tion of urinary MAU,serum NGAL and IL-27 alone(Z=2.127,2.091,2.017,P=0.033,0.037,0.044).Con-clusion The levels of urinary MAU,serum NGAL and IL-27 in DN patients were high,and the value of uri-nary MAU combined with serum NGAL and IL-27 in diagnosing DN is higher than that of each index individ-ually,and the combined detection of the three indexes can reduce the omission diagnostic rate to a certain ex-tent,provide reference value for the diagnosis of DN,and shorten the process of recovery.关键词
糖尿病肾病/尿微量清蛋白/中性粒细胞明胶酶相关脂质运载蛋白/白细胞介素-27/诊断价值Key words
diabetic nephropathy/urinary microalbumin/neutrophil gelatinase-associated lipocalin/interleukin-27/diagnostic value分类
医药卫生引用本文复制引用
杜元,宋雨轩,武智强,孙伟红..尿MAU联合血清NGAL、IL-27在糖尿病肾病诊断中的应用价值[J].检验医学与临床,2024,21(16):2385-2389,5.基金项目
河北省保定市科技计划项目(2241ZF076). （2241ZF076）
