检验医学与临床2024，Vol.21Issue(16)：2396-2399,2405,5.DOI:10.3969/j.issn.1672-9455.2024.16.018
血清CX3CL1、LTB4水平与牙列缺失患者口腔种植修复预后的关系
Relationship between serum CX3CL1 and LTB4 levels and prognosis of oral implant restoration in patients with dentition loss
摘要
Abstract
Objective To investigate the relationship between serum chemokine C-X3-C ligand 1(CX3CL1)and leukotriene B4(LTB4)levels and the prognosis of oral implant restoration in patients with dentition loss.Methods A total of 233 patients with dentition loss who received dental implant restoration in the hospital from July 2020 to June 2022 were selected as the observation group,which were subdivided into the excellent prognosis group and the poor prognosis group according to the prognosis of implants 6 months after surgery,and meanwhile 233 healthy subjects without dentition loss or defects who underwent medical checkups in the hospital were selected as the control group.The serum CX3CL1 and LTB4 levels were detec-ted in all subjects.Pearson's correlation was used to analyze the correlation between serum CX3CL1 level and LTB4 level in the patients with dentition loss.Multivariate Logistic regression was used to analyze the influen-cing factors of the poor prognosis of oral implant repair.Receiver operating characteristic(ROC)curve was used to analyze the predictive value of serum CX3CL1 and LTB4 levels for poor prognosis after oral implant repair.Results The serum CX3CL1 and LTB4 levels in the observation group were higher than those in the control group(P＜0.05).The results of Pearson correlation analysis showed that the serum CX3CL1 and LTB4 levels in the observation group were positively correlated(r=0.518,P＜0.05).In this study,192 cases had a good prognosis(excellent prognosis group),and the remaining 41 cases served as the poor prognosis group;the serum CX3CL1 and LTB4 levels in the poor prognosis group were significantly higher than those in the excellent prognosis group(P＜0.05).Multivariate Logistic regression analysis results showed that smok-ing and increased CX3CL1,LTB4 levels were independent risk factors for poor prognosis in patients with dent-al implant repair(P＜0.05).ROC curve analysis results showed that the area under the curves of serum CX3CL1 and LTB4 alone and in combination to predict poor prognosis after oral implant repair were 0.778,0.773 and 0.945,respectively.Conclusion The increased serum CX3CL1 and LTB4 levels in patients with dentition loss are closely related to the poor prognosis of oral implant restoration,which can be used to evalu-ate the prognosis of oral implant restoration.关键词
牙列缺失/口腔种植修复术/趋化因子C-X3-C基元配体1/白三烯B4/预后Key words
dentition loss/oral implant repair/chemokine C-X3-C motif ligand 1/leukotriene B4/prognosis分类
医药卫生引用本文复制引用
辜义陆,缪克红,杨凤,杨正涛..血清CX3CL1、LTB4水平与牙列缺失患者口腔种植修复预后的关系[J].检验医学与临床,2024,21(16):2396-2399,2405,5.基金项目
四川省自贡市科技计划项目(2020ZC03). （2020ZC03）
