检验医学与临床2024，Vol.21Issue(16)：2406-2410,2416,6.DOI:10.3969/j.issn.1672-9455.2024.16.020
凝血指标与PDGF-BB、ET-1在不同严重程度子痫前期中的水平及对妊娠结局的预测价值
Levels of coagulation indexes,PDGF-BB and ET-1 in preeclampsia of different severity and predictive value of pregnancy outcome
摘要
Abstract
Objective To investigate the levels of coagulation indexes[activated partial thromboplastin time(APTT),prothrombin time(PT),fibrinogen(FIB)and D-dimer(D-D)],platelet-derived growth factor BB(PDGF-BB)and endothelin-1(ET-1)in different severity of preeclampsia(PE)pregnant patients and their predictive value on pregnancy outcome.Methods A total of 118 PE pregnant patients from January 2021 to March 2023 were selected as study subjects,which were divided into PE group and severe PE group according to the severity of the disease,and 59 healthy pregnant women who underwent prenatal routine examination during the same period in the hospital were selected as the control group.The levels of APTT,PT,FIB,D-D,PDGF-BB and ET-1 were compared among the three groups.The correlation between APTT,PT,D-D,FIB,PDGF-BB,ET-1 and the severity of PE was analyzed.The PE patients were all followed up until delivery,and they were divided into good pregnancy outcome group and poor pregnancy outcome group according to the outcome of the pregnancy.The receiver operating characteristic(ROC)curve was plotted to analyze predictive efficacy of APTT,PT,D-D,FIB,PDGF-BB and ET-1 pregnancy outcome of PE patients,and the influences of APTT,PT,D-D,FIB,PDGF-BB,ET-1 on pregnancy outcome were analyzed.Results The APTT and PT in the PE group and the severe PE group were shorter than those in the control group,and the FIB,D-D,PDGF-BB and ET-1 levels were higher than those in the control group,with statistically significant differences(P＜0.05).The APTT and PT in the severe PE group were shorter than those in the PE group,and the FIB,D-D,PDGF-BB and ET-1 levels were higher than those in the PE group,with statistically significant differences(P＜0.05).Spearman correlation analysis showed that APTT and PT were negatively correlated with the se-verity of PE(r=-0.505,-0.513,P＜0.05),while FIB,D-D,PDGF-BB and ET-1 levels were positively cor-related with the severity of PE(r=0.559,0.607,0.618,0.642,P＜0.05).A total of 118 patients with PE completed follow-up,including 92 in the good pregnancy outcome group and 26 in the poor pregnancy outcome group.The APTT and PT in the poor pregnancy outcome group were shorter than those in the good pregnan-cy outcome group,and the FIB,D-D,PDGF-BB and ET-1 levels were higher than those in the good pregnancy outcome group,with statistically significant differences(P＜0.05).The results of the ROC curves analysis showed that area under the curves of APTT,PT,FIB,D-D,PDGF-BB and ET-1 to predict the pregnancy out-come of PE patients were 0.849,0.767,0.828,0.768,0.743 and 0.763,respectively,with optimal cut-off val-ues were 29.39 s,11.85 s,5.44 g/L,0.93 mg/L,116.29 ng/L,2.24 mg/L,respectively.The optimal cut-off values obtained by the ROC curves were categorized into low and high values.The risk of poor pregnancy out-come in PE patients with low values of APTT and PT was 15.231 and 7.411 times higher than that in patients with high values,and the risk of poor pregnancy outcome in PE patients with high values of FIB,D-D,PDGF-BB and ET-1 was 7.398,4.861,4.565 and 6.300 times higher than that in patients with low values.Conclusion APTT,PT,FIB,D-D,PDGF-BB and ET-1 are significantly correlated with the severity of PE,and they can be used as independent predictors for pregnancy outcomes in PE patients.关键词
子痫前期/部分凝血活酶时间/凝血酶原时间/纤维蛋白原/D-二聚体/血小板衍生生长因子-BB/内皮素-1/妊娠结局/预测价值Key words
preeclampsia/activated partial thromboplastin time/prothrombin time/fibrinogen/D-dimer/platelet-derived growth factor-BB/endothelin-1/pregnancy outcome/predictive value分类
医药卫生引用本文复制引用
孙莉莉,唐显赫,宁书芬..凝血指标与PDGF-BB、ET-1在不同严重程度子痫前期中的水平及对妊娠结局的预测价值[J].检验医学与临床,2024,21(16):2406-2410,2416,6.基金项目
河北省医学科学研究重点课题计划项目(20241788). （20241788）
