精准医学杂志2024，Vol.39Issue(4)：324-327,4.DOI:10.13362/j.jpmed.202404009
浸润性滤泡亚型甲状腺乳头状癌患者BRAF基因V600E突变的危险因素分析
Risk factors analysis for BRAF gene V600E mutation in patients with infiltrative follicular papillary thyroid carcinoma
摘要
Abstract
Objective To investigate the risk factors for BRAF gene V600E mutation in patients with infiltrative follicu-lar papillary thyroid carcinoma(IF-PTC).Methods A total of 134 patients with IF-PTC who underwent surgical treatment in our hospital from August 2019 to July 2023 were enrolled,and according to the presence or absence of BRAF gene V600E muta-tion,they were divided into mutation group and non-mutation group.The two groups were compared in terms of age,sex,and co-morbidity with Hashimoto's thyroiditis,and related indicators were collected,including the number,size,margin,calcification,echo,capsule invasion,and cervical lymph node metastasis of tumor lesions.The multivariate logistic regression model was used to investigate the risk factors for BRAF gene V600E mutation in the patients with IF-PTC.Results In this study,the patients with BRAF gene V600E mutation accounted for 67.16％.The univariate analysis showed that there were significant differences be-tween the two groups in age,the number of lesions,and the constituent ratio of patients with capsule invasion(x2=7.937-8.874,P＜0.05).The multivariate logistic regression analysis showed that age ≥55 years,multifocal tumor,and capsular invasion were independent risk factors for BRAF gene V600E mutation in IF-PTC patients(P＜0.05).Conclusion Age ≥55 years,multifo-cal tumor,and capsular invasion are independent risk factors for BRAF gene V600E mutations in IF-PTC patients.关键词
甲状腺癌,乳头状/原癌基因蛋白质B-raf/突变/危险因素Key words
Thyroid cancer,papillary/Proto-oncogene proteins B-raf/Mutation/Risk factors分类
医药卫生引用本文复制引用
李磊,战介芝,李慧,王瑞清,赵诚..浸润性滤泡亚型甲状腺乳头状癌患者BRAF基因V600E突变的危险因素分析[J].精准医学杂志,2024,39(4):324-327,4.基金项目
山东省自然科学基金面上项目(ZR2021MH403) （ZR2021MH403）
