精准医学杂志2024，Vol.39Issue(4)：337-340,4.DOI:10.13362/j.jpmed.202404012
乳腺实性乳头状癌患者144例临床分析
Clinicopathological features of patients with solid papillary carcinoma of the breast:An analysis of 144 cases
摘要
Abstract
Objective To investigate the clinicopathological features and prognosis of patients with solid papillary carci-noma(SPC)of the breast.Methods A retrospective analysis was performed for the clinical data of 144 patients with SPC of the breast who were admitted to our hospital from August 2017 to May 2023,especially the immunohistochemistry results of related pathological indicators in pathological sections,including estrogen receptor(ER),progesterone receptor(PR),human epidermal growth factor receptor 2(HER-2),Ki-67,p53,Syn,cytokeratin 5/6(CK5/6),and p63.Results Among the 144 patients,there were 142 female patients,with a mean age of(64.6±10.7)years and a median tumor largest diameter of 8.0(4.3,19.0)cm.There were 62 patients with in situ SPC,82 with invasive carcinoma,and 3 with ipsilateral axillary lymph node metastasis.Immu-nohistochemistry was performed for all 144 patients,with the positive expression of ER and the negative expression of HER-2 in all patients,among whom 130 patients(92.2％)had a Ki-67 positivity rate of ≤20％(presenting with the Luminal A immunopheno-type).Of all patients,29 underwent breast-sparing mastectomy for breast cancer,94 underwent total mastectomy,21 underwent modified radical mastectomy for breast cancer,and 98 underwent postoperative adjuvant endocrine therapy.The follow-up time was 31(16,58)months for these patients,and no recurrence or metastasis was observed.Conclusion SPC of the breast is a type of low-grade malignant tumor with special morphological features,and it often presents with the Luminal A immunophenotype.Sur-gery and endocrine therapy are the main treatment methods based on carcinoma in situ or corresponding invasive carcinoma,and patients tend to have a good prognosis.关键词
癌,乳头状/乳腺肿瘤/免疫组织化学/预后Key words
Carcinoma,papillary/Breast neoplasms/Immunohistochemistry/Prognosis分类
医药卫生引用本文复制引用
王婧楠,刘艺璇,李雪晴,孔维懋,王继纲..乳腺实性乳头状癌患者144例临床分析[J].精准医学杂志,2024,39(4):337-340,4.基金项目
山东省自然科学基金资助项目(ZR2021MH097) （ZR2021MH097）
