精准医学杂志2024，Vol.39Issue(4)：352-355,4.DOI:10.13362/j.jpmed.202404015
TLR3基因单核苷酸多态性与儿童紫癜性肾炎的相关性
Association of single nucleotide polymorphisms of the TLR3 gene with Henoch-Schönlein purpura in children
摘要
Abstract
Objective To investigate the association of single nucleotide polymorphisms of the TLR3 gene with suscepti-bility to Henoch-Schönlein purpura(HSP)and Henoch-Schönlein purpura nephritis(HSPN)in children.Methods A total of 174 children with HSP were enrolled as case group,and 162 healthy children who underwent physical examination during the same period of time were enrolled as control group.The children in the case group were divided into HSP group and HSPN group accor-ding to the presence or absence of renal damage during follow-up.Multiplex polymerase chain reaction was used for targeted capture of the rs35311343,rs121434431,rs199768900,rs768091235,and rs1244010954 loci of the TLR3 gene,high-throughput sequen-cing was performed for the above loci of all samples,and a statistical analysis was performed for the genotype and gene frequency of each locus.Results There were no significant differences in the genotype and allele frequencies of the rs35311343,rs121434431,rs199768900,rs768091235,and rs1244010954 loci of the TLR3 gene between the case group and the control group(P＞0.05).For the case group,there were no significant differences in the genotype and allele frequencies of the rs121434431,rs199768900,rs768091235,and rs1244010954 loci of the TLR3 gene between the HSP group and the HSPN group(P＞0.05),while there was a significant difference in the genotype and allele frequencies of the rs35311343 locus between the two groups(x2=9.492,OR=2.662,95％CI=1.342-5.281,P＜0.05).Conclusion The CG genotype of the rs35311343 locus of the TLR3 gene is associated with renal involvement in children with HSP,and allele G may be a susceptibility gene for HSPN.关键词
紫癜,过敏性/Toll样受体3/多态性,单核苷酸/肾炎/高通量核苷酸序列分析/儿童Key words
Purpura,schoenlein-henoch/Toll-like receptor 3/Polymorphism,single nucleotide/Nephritis/High-throughput nucleotide sequencing/Child分类
医药卫生引用本文复制引用
屈凤祥,常红,林毅..TLR3基因单核苷酸多态性与儿童紫癜性肾炎的相关性[J].精准医学杂志,2024,39(4):352-355,4.基金项目
青岛大学附属医院临床医学+X科研项目(2019+X017) （2019+X017）
