精准医学杂志2024，Vol.39Issue(4)：367-370,4.DOI:10.13362/j.jpmed.202404018
上皮细胞黏附分子与肺癌、乳腺癌及部分消化系统肿瘤关系的研究进展
Research advances in the association of epithelial cell adhesion molecule with lung cancer,breast cancer,and some digestive system tumors
摘要
Abstract
Epithelial cell adhesion molecule(EpCAM)was first identified in colon cancer cells and is involved in the regu-lation of cell adhesion,proliferation,differentiation,migration,and signal transduction.Normally,EpCAM is only expressed in normal epithelial cells,but studies have shown that it is present and highly expressed in human epithelial cell-derived malignant tumors.EpCAM is involved in multiple links of tumor progression,and its unique expression pattern in tumor has also made it one of the most important tumor biomarkers.This article reviews the research advances in EpCAM as a tumor biomarker in recent years and its potential application in the treatment of lung cancer,breast cancer,and some digestive system tumors.These studies reveal the important role of EpCAM in tumor progression and provide a scientific basis for its potential as a therapeutic target.关键词
上皮细胞黏附分子/肺肿瘤/乳腺肿瘤/结肠肿瘤/胃肿瘤/肝肿瘤/生物标记,肿瘤/综述Key words
Epithelial cell adhesion molecule/Lung neoplasms/Breast neoplasms/Colonic neoplasms/Stomach neo-plasms/Liver neoplasms/Biomarkers,tumor/Review分类
医药卫生引用本文复制引用
崔佳丽,王清..上皮细胞黏附分子与肺癌、乳腺癌及部分消化系统肿瘤关系的研究进展[J].精准医学杂志,2024,39(4):367-370,4.基金项目
山东省重点研发计划项目(GG201809180014) （GG201809180014）
