精准医学杂志2024，Vol.39Issue(5)：393-396,4.DOI:10.13362/j.jpmed.202405004
实时组织弹性成像技术对肝移植患者供肝质量及术后EAD发生的评估价值
Value of real-time tissue elastography in evaluating donor liver quality and postoperative early al-lograft dysfunction in liver transplantation patients
摘要
Abstract
Objective To investigate the value of real-time tissue elastography(RTE)in evaluating donor liver quality and postoperative early allograft dysfunction(EAD)in liver transplantation patients.Methods A total of 58 patients who re-ceived liver transplantation in Organ Transplantation Center of our hospital from October 2020 to January 2022 were enrolled,and according to the recovery of liver function in the early stage after surgery,the patients were divided into EAD group and non-EAD group.The two groups were compared in terms of the indicators such as the routine ultrasound examination and RTE measurement of donor liver before liver transplantation,liver function and coagulation function of recipients before and after liver transplanta-tion,and preoperative Model for End-Stage Liver Disease(MELD)score.The logistic regression analysis was performed for the in-dicators with significant differences,and the receiver operating characteristic(ROC)curve was plotted to calculate the area under the ROC curve(AUC)and assess the performance of related factors.Results Compared with the non-EAD group,the EAD group had significantly higher liver fibrosis(LF)index of donor liver and MELD score of recipients(t=4.822,2.902,P＜0.05).The logistic regression analysis showed that donor liver LF index＞1.645 was a risk factor for EAD after liver transplantation,and the ROC curve analysis showed that donor liver LF index had an AUC of 0.840 in predicting EAD after surgery,with a sensitivity of 82.4％,a specificity of 73.2％,and a cut-off value of 1.645.Conclusion High LF index of donor liver before liver transplan-tation is a risk factor for EAD in recipients after liver transplantation,and RTE measurement for LF index of donor liver before li-ver transplantation has a certain value in assessing the quality of donor liver and predicting the onset of EAD.关键词
肝移植/弹性成像技术/肝硬化/移植物功能延迟恢复/Logistic模型/危险因素/敏感性与特异性Key words
Liver transplantation/Elasticity imaging techniques/Liver cirrhosis/Delayed graft function/Logistic mo-dels/Risk factors/Sensitivity and specificity分类
医药卫生引用本文复制引用
杨山,褚夫娟,张迪,吴晓冬,杨子祯,王建红..实时组织弹性成像技术对肝移植患者供肝质量及术后EAD发生的评估价值[J].精准医学杂志,2024,39(5):393-396,4.基金项目
青岛大学附属医院临床医学+X科研项目(QYFY+X202101060) （QYFY+X202101060）
