精准医学杂志2024，Vol.39Issue(5)：431-434,4.DOI:10.13362/j.jpmed.202405013
不同抗生素联合替加环素治疗MDRAB相关VAP患者效果比较
Effect of different antibiotics combined with tigecycline in patients with multidrug-resistant Acineto-bacter baumannii-related ventilator-associated pneumonia:A comparative study
摘要
Abstract
Objective To investigate the effect of different antibacterial agents combined with tigecycline in patients with multidrug-resistant Acinetobacter baumannii(MDRAB)-related ventilator-associated pneumonia(VAP),and to provide options for better treatment of the disease in clinical practice.Methods A retrospective analysis was performed for the clinical data of the patients with MDRAB-related VAP who were admitted from January 2016 to August 2023 in Qingdao municipal Hospital,and according to the treatment regimen,they were divided into tigecycline group(group A)with 56 patients,cefoperazone-sulbactam combination therapy group(B group)with 42 patients,and carbapenem combination therapy group(group C)with 24 patients.The three groups were compared in terms of infection and related outcome measures.Results There were no significant diffe-rences in the type of pathogene infected and infection sites between the three groups(P＞0.05).Groups B and C had a significantly higher bacterial clearance rate than group A(x2=5.38,4.48,P＜0.05),and there was no significant difference in in-hospital mor-tality rate between the three groups(P＞0.05).Conclusion Tigecycline combined with cefoperazone-sulbactam or carbapenem achieves a higher bacterial clearance rate than tigecycline alone in MDRAB-related VAP,and combined medication is a relatively good treatment option.关键词
替加环素/肺炎,呼吸机相关性/鲍氏不动杆菌/抗药性,细菌/疗效比较研究Key words
Tigecycline/Pneumonia,ventilator-associated/Acinetobacter baumannii/Drug resistance,bacterial/Com-parative effectiveness research分类
医药卫生引用本文复制引用
石新艳,尚宁,王虹,杨婷婷,赵春玲,齐卫卫,刘伟..不同抗生素联合替加环素治疗MDRAB相关VAP患者效果比较[J].精准医学杂志,2024,39(5):431-434,4.基金项目
国家自然科学基金项目(81602068) （81602068）
