以脊柱关节痛为首发症状的布氏杆菌病患者的血清学检测分析OA
Serological Analysis of Brucellosis Patients with Spinal Joint Pain as the First Symptom
目的:探讨与分析以脊柱关节痛为首发症状的布氏杆菌病患者的血清学检测价值.方法:选择 2020年 4月—2023年 2月青海省西宁市大通回族土族自治县疾病预防控制中心收治的 86例布氏杆菌病患者作为研究对象,其中以脊柱关节痛为首发症状的 36例患者为关节痛组,非以脊柱关节痛为首发症状的 50例患者为对照组,检测 2组的血清学指标,判定患者的脊柱关节疼痛情况并进行相关性分析.结果:2组的白细胞、红细胞、血红蛋白、血小板计数等对比,组间差异无统计学意义(P>0.05).关节痛组的血清抗核抗体、抗角蛋白抗体、抗滑膜环瓜氨酸肽抗体、基质金属蛋白酶-3含量均高于对照组,血清 1,25-二羟基维生素D3 含量均低于对照组,差异有统计学意义(P<0.05).关节痛组的脊柱关节疼痛VAS评分明显高于对照组,差异均有统计学意义(P<0.05).在 86例患者中,Pearson分析显示,血清抗核抗体、抗角蛋白抗体、抗滑膜环瓜氨酸肽抗体、基质金属蛋白酶-3、1,25-二羟基维生素D3 含量与脊柱关节视觉模拟量表(VAS)评分存在相关性,差异均有统计学意义(P<0.05).二元logistic回归分析显示,血清抗核抗体、抗角蛋白抗体、抗滑膜环瓜氨酸肽抗体、基质金属蛋白酶-3、1,25-二羟基维生素D3 含量为影响脊柱关节疼痛VAS评分的重要因素,差异均有统计学意义(P<0.05).结论:以脊柱关节痛为首发症状的布氏杆菌病患者比较常见,多表现为血清抗核抗体、抗角蛋白抗体、抗滑膜环瓜氨酸肽抗体、基质金属蛋白酶-3含量增高与血清1,25-二羟基维生素D3 含量降低,加强血清学检测具有重要的临床意义.
Objective:To explore and analyze the value of serologic detection in brucellosis patients with spinal arthralgia as the first symptom.Methods:86 cases of brucellosis in Datong Hui Tu autonomous county center for disease control and prevention from April 2020 to February 2023 were selected as the research objects,among which 36 cases of patients with spinal joint pain as the first symptom were selected as the arthralgia group,and 50 cases of patients without spinal joint pain as the first symptom were selected as the control group.Serological indexes of the two groups were detected to determine the spinal joint pain of patients and conduct correlation analysis.Results:There were no significant differences in leukocyte,erythrocyte,hemoglobin and platelet count between 2 groups(P>0.05).The contents of anti-nuclear antibody,anti-keratin antibody,anti-synoviocyclic citrulline peptide antibody and matrix metalloproteinase-3 in arthralgia group were higher than those in control group,and the contents of 1,25-dihydroxyvitamin D3 in serum were lower than those in control group,with statistical significance(P<0.05).The spinal joint pain VAS score of the arthralgia group was significantly higher than that of the control group,and the differences were statistically significant(P<0.05).Among 86 patients,Pearson analysis showed that serum levels of anti-nuclear antibody,anti-keratin antibody,anti-synovial cyclocitcitine peptide antibody,matrix metalloproteinase-3,1,25-dihydroxyvitamin D3 were correlated with VAS scores of spinal joint pain,with statistical significance(P<0.05).Binary logistic regression analysis showed that serum levels of anti-nuclear antibody,anti-keratin antibody,anti-synovial ring citcitine peptide antibody,matrix metalloproteinase-3 and 1,25-dihydroxyvitamin D3 were important factors affecting the VAS score of spinal joint pain,and the differences were statistically significant(P<0.05).Conclusion:Brucellosis patients with spinal arthralgia as the first symptom are relatively common,most of which are manifested as serum anti-nuclear antibody,anti-keratin antibody,anti-synovial cyclamate citroline peptide antibody,increased content of matrix metalloproteinase-3 and decreased content of serum 1,25-dihydroxyvitamin D3,strengthening serological detection has important clinical significance.
赵士霞;赵士杰
青海省西宁市大通回族土族自治县疾病预防控制中心检验科,青海 西宁 810100青海省人民医院检验科
临床医学
脊柱关节痛首发症状布氏杆菌病抗核抗体抗角蛋白抗体抗滑膜环瓜氨酸肽抗体
Spinal arthralgiaThe first symptomsBrucellosisAnti-nuclear antibodyAnti-keratin antibodyAntibody against synovial cyclic citrulline peptide
《中国伤残医学》 2024 (011)
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