中国伤残医学2024，Vol.32Issue(11)：9-12,4.DOI:10.13214/j.cnki.cjotadm.2024.011.003
托法替布对类风湿关节炎患者的干预效果分析
Analysis of Intervention Effect of Tofacatib on Patients with Rheumatoid Arthritis
摘要
Abstract
Objective:To explore and analyze the intervention effect of tofacatib on patients with rheumatoid arthritis.Methods:80 patients with rheumatoid arthritis in our hospital from June 2021 to January 2023 were selected as research objects,and were divided into a Tofacitib group and a control group according to random number table method,with 40 cases each.The control group was treated with methotrexate,and the tofacatib group was treated with tofacatib on the basis of the control group.Both groups were observed for 12 weeks,and the degree of synovial hyperplasia and changes in bone erosion,musculoskeletal ultrasound semi-quantitative score,quality of life score and incidence of adverse reactions during treatment were compared between the two groups.Results:The bone erosion score and synovial hyperplasia score of the 2 groups after 12 weeks of treatment were lower than before treatment,and the bone erosion score and synovial hyperplasia score of the Tofacatib group after 12 weeks of treatment were lower than the control group,with statistical significance(P<0.05).There was no significant difference in the incidence of adverse reactions such as nausea,vomiting,lethargy,venous thrombosis and leukopenia between 2 groups during treatment(P>0.05).The musculoskeletal ultrasound semi-quantitative score after 12 weeks of treatment in both groups was lower than before treatment,and the musculoskeletal ultrasound semi-quantitative score after 12 weeks of treatment in Tofacitib group was also lower than that in control group,with statistical significance(P<0.05).After 12 weeks of treatment,life quality scores such as functional status,emotional status,social function and physiological function in Tofacatib group were higher than those in control group,and the differences were statistically significant(P<0.05).Conclusion:The application of tofacatib in patients with rheumatoid arthritis can alleviate the degree of synovial hyperplasia and bone erosion without increasing the occurrence of adverse reactions,and can also reduce the semi-quantitative musculoskeletal ultrasound score of patients,improve the quality of life of patients,and thus continue to improve the prognosis of patients.关键词
类风湿关节炎/滑膜增生/托法替布/不良反应/C-反应蛋白/骨侵蚀/核因子kB受体活化因子配体Key words
Rheumatoid arthritis/Synovial hyperplasia/Tofaciib/Adverse reactions/C-reactive protein/Bone erosion/Nuclear factor kB receptor activation factor ligand分类
医药卫生引用本文复制引用
雷尚文,张晓莉,李子佳,张佳红..托法替布对类风湿关节炎患者的干预效果分析[J].中国伤残医学,2024,32(11):9-12,4.基金项目
甘肃省自然科学基金项目(21JR11RA188) （21JR11RA188）
