糖尿病足血清学诊断标志物的研究进展OA北大核心CSTPCD

Diabetic foot(DF),a primary chronic complication of diabetes mellitus,contributes to a major disability and mortality in diabetic patients.DF is diagnosed mainly depending not only on clinical manifestations,signs,and related inspection,but also on recently emerging diagnostic means:biological markers.Inflammatory biomarkers are preferably used for its superiority in DF early diagnosis.In recently years,thanks to advancements of biological technologies,biomarkers such as procalcitonin(PCT),C-reactive protein(CRP),interleukins(ILs),and tumor necrosis factor-alpha(TNF-α)have been comprehensively used in DF diagnosis.Moreover,biomarkers of genomics,proteomics,metabolomics,and metagenomics have been employed as well.In this review,we aim to com-prehensively review the role of serum biomarkers in DF diagnosis and risk stratification,elaborating on the current research status in applying serum biomarkers for DF prevention,diagnosis,and prognosis assessment.