实用医学杂志2024，Vol.40Issue(16)：2224-2228,5.DOI:10.3969/j.issn.1006-5725.2024.16.005
糖尿病足血清学诊断标志物的研究进展
Serological biomarkers for diagnosis of diabetes foot:A review of literature
摘要
Abstract
Diabetic foot(DF),a primary chronic complication of diabetes mellitus,contributes to a major disability and mortality in diabetic patients.DF is diagnosed mainly depending not only on clinical manifestations,signs,and related inspection,but also on recently emerging diagnostic means:biological markers.Inflammatory biomarkers are preferably used for its superiority in DF early diagnosis.In recently years,thanks to advancements of biological technologies,biomarkers such as procalcitonin(PCT),C-reactive protein(CRP),interleukins(ILs),and tumor necrosis factor-alpha(TNF-α)have been comprehensively used in DF diagnosis.Moreover,biomarkers of genomics,proteomics,metabolomics,and metagenomics have been employed as well.In this review,we aim to com-prehensively review the role of serum biomarkers in DF diagnosis and risk stratification,elaborating on the current research status in applying serum biomarkers for DF prevention,diagnosis,and prognosis assessment.关键词
糖尿病足/诊断标志物/血清学标志物Key words
diabetic foot/diagnostic marker/serological biomarkers分类
医药卫生引用本文复制引用
杨卡明,李贞林,劳琬文,翟爱霞,毕长龙..糖尿病足血清学诊断标志物的研究进展[J].实用医学杂志,2024,40(16):2224-2228,5.基金项目
国家自然科学基金项目(编号:82172215,82272271) （编号:82172215,82272271）
广东省基础与应用基础研究基金项目(编号:2021A1515012109) （编号:2021A1515012109）
深圳市科技创新委员基础研究专项面上项目(编号:JCYJ20230807111302006) （编号:JCYJ20230807111302006）
深圳市福田区卫生健康系统科研项目(编号:FTWS2023056,FTWS2023008) （编号:FTWS2023056,FTWS2023008）
