实用医学杂志2024，Vol.40Issue(16)：2244-2249,6.DOI:10.3969/j.issn.1006-5725.2024.16.008
血清miR-23a、miR-150、miR-150-5p水平与糖尿病性骨质疏松症的相关性
Correlation between serum levels of miR-23a,miR-150,and miR-150-5p and diabetic osteoporosis
摘要
Abstract
Objective To investigate the association between microRNA(miR)-23a,miR-150,and miR-150-5p levels and diabetic osteoporosis(DOP)through correlation analysis.Methods A total of 200 patients with diabetes who visited the hospital between March 2020 and March 2022 were selected and followed up for a duration of 2 years.Patients who developed DOP and those who did not were respectively assigned to the DOP group and the non-DOP group.The general information and serum levels of miR-23a,miR-150,and miR-150-5p between these two groups were compared.Pearson correlation analysis was conducted to examine the relationship between serum levels of miR-23a,miR-150,and miR-150-5p,as well as bone density.Logistic regression model was employed to identify factors influencing DOP.Results The incidence rate of DOP was 28.89%.The serum levels of miR-23a,miR-150,and miR-150-5p were significantly elevated in the DOP group compared to the non-DOP group(P＜0.05).Pearson correlation analysis revealed a negative association between the serum levels of miR-23a,miR-150,and miR-150-5p in diabetic patients and bone density(P＜0.05).Logistic regression model analysis demonstrated that age,body mass index(BMI),as well as miR-23a,miR-150,and miR-150-5p were influential factors contributing to the development of DOP(P＜0.05).Conclusion The levels of serum miR-23a,miR-150,and miR-150-5p are elevated in patients with DOP,and all three exhibit a negative correlation with bone density.Furthermore,these factors collectively contribute to the development of DOP.关键词
糖尿病/骨质疏松症/微小核糖核酸-23a/微小核糖核酸-150/微小核糖核酸-150-5pKey words
diabetes/osteoporosis/microRNA-23a/microRNA-150/microRNA-150-5p分类
医药卫生引用本文复制引用
孙晓利,范慧洁..血清miR-23a、miR-150、miR-150-5p水平与糖尿病性骨质疏松症的相关性[J].实用医学杂志,2024,40(16):2244-2249,6.基金项目
河南省医学科技攻关计划项目(编号:LHGJ20200690) （编号:LHGJ20200690）
