实用医学杂志2024，Vol.40Issue(16)：2311-2315,5.DOI:10.3969/j.issn.1006-5725.2024.16.018
基于静息态磁共振分析首发抑郁症伴童年创伤全脑局部一致性变化
Analysis of global local consistency changes in first-episode depression with childhood maltreatment based on resting-state magnetic resonance
摘要
Abstract
Objective This study used resting-state functional magnetic resonance imaging(rs-fMRI)to investigate the changes of local brain regional homogeneity in patients with depression and childhood maltreatment,and we calculated the relationship between altered ReHo values and the severity of childhood maltreatment.Methods 25 patients with depression and childhood maltreatment,25 patients with depression without childhood maltreatment,and 25 age,gender,and education-matched healthy controls were prospectively enrolled.All subjects underwent resting-state functional magnetic resonance imaging and ReHo analysis.One-way analysis of variance was used to compare the group differences,along with multiple comparison correction.Pearson correlation analysis was used to explore the relationship between region ReHo values with clinical scales.Results Compared with the group of depression without childhood maltreatment,the abnormal brain regions of depression with childhood maltreatment are mainly located in the dorsolateral prefrontal cortex,cerebellum,parietal gyrus,and precentral gyrus.The ReHo values of depression with childhood maltreatment in the left cerebellum and the left dorsolateral prefrontal cortex are correlated with the severity of childhood maltreatment.Conclusions Depression with childhood mal-treatment is associated with changes in local spontaneous brain activity,which are correlated with the severity of childhood maltreatment.The brain changes in the dorsolateral prefrontal cortex and cerebellum may explain the neurobiological mechanisms of depression with childhood maltreatment.关键词
抑郁症/童年创伤/静息态/功能磁共振成像/局部一致性Key words
depression/childhood maltreatment/resting state/functional magnetic resonance imag-ing/regional homogeneity分类
医药卫生引用本文复制引用
王頔,廖旦,刘远成,徐睿,段庆红..基于静息态磁共振分析首发抑郁症伴童年创伤全脑局部一致性变化[J].实用医学杂志,2024,40(16):2311-2315,5.基金项目
贵州省科技计划项目(编号:黔科合支撑[2021]一般451) （编号:黔科合支撑[2021]一般451）
中华国际医学交流基金会2021SKY影像科研基金(编号:Z-2014-07-2101) （编号:Z-2014-07-2101）
