天津中医药2024，Vol.41Issue(8)：963-967,5.DOI:10.11656/j.issn.1672-1519.2024.08.03
复方丹参滴丸对冠心病合并糖尿病患者介入治疗后造影剂肾病的预防作用
Preventive effect of Compound Danshen Dripping Pill on contrast nephropathy after percutaneous coronary intervention among the patients with coronary artery disease complicated with diabetes mellitus
摘要
Abstract
[Objective]To investigate the protective effect of Compound Danshen Dripping Pills on contrast-induced acute kidney injury(CIAKI)among the patients with coronary artery disease complicated with diabetes.[Methods]One hundred and eighty patients with diabetes and coronary artery disease who were admitted in Tianjin Chest Hospital from January,2022 to January,2023 and scheduled for interventional therapy were randomly divided into observe group(90),receiving additional Compound Danshen Dripping Pills on the basis of the control group,and the control group(90),receiving hydration therapy to prevent CIN.The incidence of contrast nephropathy rate,and the renal function of the two groups before and 72 hours after treatment was compared.The levels of renal function indexes(BUN,Scr,eGFR,β2-microglobulin,ACR and NGAL),inflammatory reaction indexes(hs-CRP,IL-6),and oxidative stress indexes(malondialdehyde and SOD)were measured before and after treatment.The patients were followed up 6 months and record the occurrence of major adverse cardiac events(MACE)in both groups.[Results]1)The treatment group had statistically lower incidence of CIAKI than the control group(4.4％vs 16.7％,P＜0.05).2)Before treatment,no significant differences of clinical background factors between the two groups were found(P＞0.05).The levels of Scr,BUN,β2-microglobulin,hs-CRP,IL-6,malondialdehyde,protein-creatinine ratio(ACR)and neutrophil gelatinase associated lipocalin(NGAL)were significantly increased,while the eGFR and SOD were obviously decreased in both groups in 72 h after treatment(P＜0.05).In 72 h after treatment,the levels of Scr,BUN,β2-microglobulin,hs-CRP,IL-6,malondialdehyde,protein-creatinine ratio(ACR)and neutrophil gelatinase associated lipocalin(NGAL)were notably lower,and the eGFR and SOD were remarkably higher in the Compound Danshen Dripping Pills group than the control group(all P＜0.05).3)Following up for 6 months,the incidence of adverse prognosis in the Compound Danshen Dripping Pills group was lower than that in control group,with significant difference(10.0％vs 31.3％,P＜0.05).4)Multivariate logistic regression analysis showed that Compound Danshen Dripping Pills had positive effect on the prevention of CIAKI[OR=0.136,95％CI(0.035,0.527),P=0.004].[Conclusion]Compound Danshen Dripping Pills may exert certain preventive effect on the development of CIAKI among the patients with diabetes and coronary artery disease in the interventional therapy.关键词
复方丹参滴丸/造影剂肾病/经皮冠状动脉介入治疗/冠心病/糖尿病/预防Key words
Compound Danshen Dripping Pill/contrast nephropathy/percutaneous coronary intervention/coronary artery disease/diabetes mellitus/prevent分类
医药卫生引用本文复制引用
席鹏丽,杨世诚,宫鑫成,英硕,张鹏..复方丹参滴丸对冠心病合并糖尿病患者介入治疗后造影剂肾病的预防作用[J].天津中医药,2024,41(8):963-967,5.基金项目
天津市卫生健康委员会天津市中医药管理局中医中西医结合科研课题(2021205) （2021205）
天津市医学重点建设学科(心血管病学)建设项目(TJYXZDXK-055B). （心血管病学）
