四白汤对乙醇诱导下小鼠胃溃疡的防治作用研究OACSTPCD
Research on the protective effect of Sibai Decoction on ethanol-induced gastric ulcers in mice
[目的]探讨四白汤方(SBT)对乙醇(EtOH)诱导下胃溃疡(GU)模型小鼠胃黏膜损伤的防治作用及其分子机制,为其临床治疗GU提供理论依据.[方法]体外实验将5组小鼠灌服高、中、低剂量SBT 7 d后取血分离血清,用于培养细胞建立血清学研究模型.含药血清的培养基培养人胃黏膜上皮细胞-1(GES-1),细胞进入G0期后加入0.8 mol/L EtOH处理4 h建立GES-1细胞损伤模型,采用细胞计数试剂盒-8(CCK8)法检测EtOH处理后的细胞的…查看全部>>
[Objective]This study aims to investigate the prophylactic and therapeutic effects of Sibai Decoction(SBT)on gastric ulcers(GU)induced by ethanol(EtOH)in mice,and to explore its underlying molecular mechanisms,thus providing a theoretical basis for its clinical application in treating GU.[Methods]In vitro,five groups of mice were administered with high,medium,and low doses of SBT for 7 days,after which blood was collected to separate serum for the establishm…查看全部>>
李平香;高瑞阳;李景尧;郑艳
青岛大学医学部中西医结合学科,青岛 266023青岛大学医学部中西医结合学科,青岛 266023青岛大学医学部中西医结合学科,青岛 266023青岛市中医医院(市海慈医院)青岛大学附属青岛市海慈医院,青岛 266033
中医学
四白汤乙醇胃溃疡抗氧化应激抗炎
Sibai Decoctionethanolgastric ulcerantioxidant stressanti-inflammatory
《天津中医药》 2024 (8)
1030-1038,9
青岛市2015-2016年度中医药研究计划(2015-zyy013).
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