天津中医药2024，Vol.41Issue(8)：1075-1082,8.DOI:10.11656/j.issn.1672-1519.2024.08.21
mTOR信号通路调控糖尿病肾病足细胞自噬机制及中医药的干预作用研究进展
Review of the mechanism of mTOR signaling pathway regulating podocyte autophagy in diabetes kidney disease and the intervention of traditional Chinese medicine
摘要
Abstract
Diabetic kidney disease(DKD)as a severe microvascular complication of diabetes is the major cause of end-stage renal failure.Its progress cannot be delayed by drugs and increases the mortality of diabetes patients.Early prevention and treatment of DKD is a top priority in clinical practice.Podocytes are an important part of the glomerular filtration barrier.The imbalance of their autophagy level usually occurs in the early stage of DKD,which has potential value for the progress of DKD.The mTOR signal pathway is a classic pathway to regulate podocyte autophagy,and plays an important role in the development of diabetes nephropathy as a nutritional sensing pathway.Traditional Chinese medicine has unique advantages and good prospects in the prevention and treatment of DKD.Traditional Chinese medicine for invigorating qi,nourishing yin and activating blood circulation is commonly used in clinical treatment of DKD.The clarification of its potential mechanism will help to provide scientific basis for clinical treatment,guide the research and development of new drugs,and promote the modernization process of traditional Chinese medicine.Therefore,this article reviews the research related to the regulation of podocyte autophagy level by traditional Chinese medicine monomer or compound targeting mTOR signal pathway to prevent and treat diabetes nephropathy,in order to provide a reference for clinical pharmacological research and clinical application of prevention and treatment of DKD by traditional Chinese medicine.关键词
足细胞自噬/mTOR信号通路/糖尿病肾病/中医药/PI3K/Akt/mTOR信号通路Key words
podocyte autophagy/mTOR signaling pathway/diabetic kidney disease/traditional Chinese medicine/PI3K/Akt/mTOR pathway分类
医药卫生引用本文复制引用
李艳芳,刘佳,黄宇虹..mTOR信号通路调控糖尿病肾病足细胞自噬机制及中医药的干预作用研究进展[J].天津中医药,2024,41(8):1075-1082,8.基金项目
国家自然科学基金青年项目(81903768) （81903768）
国家新药创制重大专项(2015ZX09101043-009). （2015ZX09101043-009）
