同位素2024，Vol.37Issue(4)：379-386,8.DOI:10.7538/tws.2024.youxian.015
[18F]AlF-NOTA-TATE的制备及初步临床应用
Preparation and Preliminary Clinical Application of[18F]AlF-NOTA-TATE
摘要
Abstract
68Ga-DOTA-TATE has been successfully applied in the diagnosis of clinical neuroendocrine tumors,but its short half-life limits its widespread use.This study aimed to develop[18F]AlF-NOTA-TATE to meet the clinical demands of patients with neuroendocrine tumors(NETs)for diagnosis and treatment evaluation.A new column chromatography purification method for[18F]AlF-NOTA-TATE was developed and automated synthesis was performed using a clinical single-vessel multi-functional fluorine synthesis module.The lipophilicity,in vitro stability,and pharmacokinetics of[18F]AlF-NOTA-TATE were studied,and biodistribution experiments and PET/CT imaging of nude mice with NCI-H69(SSTR2 positive expression)small cell lung cancer were conducted,followed by preliminary clinical evaluation on three patients with neuroendocrine tumors.The new column chromatography purification method for[18F]AlF-NOTA-TATE was simple,which was synthesized in a short time with higher than 95％of radiochemical purity and,less than 3％of.ethanol content.Pharmacokinetic and biodistribution experiments in BALB/c mice showed rapid blood clearance of the drug and renal metabolism.PET/CT imaging of tumor-bearing mice showed specific uptake of the radiotracer in SSTR-positive tumors.Preliminary clinical application showed that[18F]AlF-NOTA-TATE is well targeted in patients with long retention time and can provide better image quality.The column chromatography method for the preparation of[18F]AlF-NOTA-TATE was simple and had high radiochemical purity.Preliminary clinical results suggested that[18F]AlF-NOTA-TATE has further value for clinical research.关键词
[18F]AlF-NOTA-TATE/柱色层纯化/神经内分泌肿瘤/临床应用Key words
[18F]AlF-NOTA-TATE/column color layer purification/neuroendocrine tumors/clinical application分类
能源科技引用本文复制引用
刘欢欢,张晓军,麻广宇,张锦明..[18F]AlF-NOTA-TATE的制备及初步临床应用[J].同位素,2024,37(4):379-386,8.基金项目
国家同位素工程技术研究中心开放课题资助项目(GJTESGCZX-202307) （GJTESGCZX-202307）
