4-苯基丁酸钠盐抑制肝组织凋亡减轻脓毒症肝损伤的机制研究OACSTPCD
Study on the mechanism of inhibiting liver tissue apoptosis by 4-phenylbutyrate sodium salt and alleviating liver injury in sepsis
目的 探讨 4-苯基丁酸钠盐(4-PBA)对脓毒症小鼠肝损伤的保护作用及其信号机制.方法 小鼠随机分为3 组:假手术组(Sham组)、脓毒症组小鼠(模型组,LPS组)及实验组小鼠(治疗组,LPS+4-PBA组),每组5 只.LPS术后24 h,分别观察各组小鼠一般情况、脓毒症严重程度评分、肝功能、肝组织炎症指标、细胞凋亡程度.Western blot 检测各组小鼠肝组织凋亡相关蛋白Bax、Bcl-2和内质网应激相关蛋白ATF4、CHOP 的表达水…查看全部>>
Objective To investigate the protective effect of 4-phenylbutyrate(4-PBA)on liver apoptosis in septic mice and its signaling mechanism.Methods The mice were randomly divided into 3 groups:Sham operation group(Sham group),sepsis group(model group,LPS group),and experimental group(treatment group,LPS+4-PBA group).At 24h after LPS,the general condition,sepsis severity score,liver function,liver tissue inflammation index and liver tissue apoptosis degree of mice…查看全部>>
付靖楠;周黎
300162 天津,武警特色医学中心特勤急救外科300162 天津,武警特色医学中心肾脏病科
临床医学
4-苯基丁酸钠盐脓毒症质网应激细胞凋亡
4-PBAsepsisendoplasmic reticulum stressapoptosis of cells
《武警医学》 2024 (8)
667-671,675,6
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