武警医学2024，Vol.35Issue(8)：694-698,5.
社区高龄老人甲状腺激素水平与身体虚弱之间的关系
Relationship between thyroid hormone levels and frailty in elderly community members
摘要
Abstract
Objective To analyze the relationship between thyroid hormones(THs),frailty and the five components of frailty phenotype(fatigue,resistance,walking ability,number of illnesses,and weight loss)in the elderly.Methods Cross-sectional study with 487 community-dwelling elderly residents aged≥80 years was conducted.A clear diagnosis of frailty was made based on the FRAIL scale(fatigue,resistance,walking,disease,and weight loss),and positive scores were recorded for each frailty subdomain.Demographic information(age,sex,marital status and education),comorbidities,and details of the participants'lifestyles were also recorded.Laboratory tests were performed to determine serum THs,including free triiodothyronine(fT3),triiodothyronine(T3),free thyroxine(fT4),and thyroxine(T4),and thyroid stimulating hormone(TSH)levels.logistic regression of the data was performed to screen out potential risk factors for frailty and its subdomains.Results Of the 487 subjects enrolled,60(12.23%)were diagnosed with subclinical hypothyroidism,and 110(22.59%)had a positive frailty score.Logistic regression analysis adjusted for all potential confounders showed that frailty was significantly associated with serum TSH concentration(OR:1.06),fT3 concentration(OR:0.54),and subclinical hypothyroidism(OR:2.18).The study showed no association between fT4 and frailty,whereas fT3/fT4 was associated with frailty.Conclusions Subclinical hypothyroidism,higher TSH levels,lower fT3 levels,and lower fT3/fT4 ratio are all associated with frailty as assessed by the FRAIL scale in community-dwelling elderly.Future longitudinal studies are needed to continue to deter-mine the association between thyroid dysfunction and frailty in the elderly.关键词
甲状腺功能减退/虚弱/老龄化/甲状腺激素/促甲状腺激素Key words
hypothyroidism/frailty/aging/thyroid hormone/thyroid stimulating hormone分类
医药卫生引用本文复制引用
刘昱彤,陈薇,高扬,管博,刘睿涵,杨明艳,曹剑..社区高龄老人甲状腺激素水平与身体虚弱之间的关系[J].武警医学,2024,35(8):694-698,5.基金项目
军队某课题资助 （）
国家老年疾病临床医学研究中心开放课题(NCRCG-PLAGH-2022004) （NCRCG-PLAGH-2022004）
