现代医药卫生2024，Vol.40Issue(16)：2813-2819,7.DOI:10.3969/j.issn.1009-5519.2024.16.025
微小RNA-324-5p在恶性肿瘤中的作用及其机制研究进展
Research progress on the role and mechanism of microRNA-324-5p in malignant tumors
摘要
Abstract
MicroRNAs(miRNA)is a class of non-coding single-stranded RNAs with length of about 19-25 nucleotides,which can completely or incompletely bind to the 3'ntranslated region(3'UTR)of the tar-get gene,inhibit the translation of messenger RNAs or promote its degradation,and exert post-transcriptional regulatory effects.At present,it has been found that the expression of miR-324-5p is abnormal in a variety of malignant tumors,and miR-324-5p regulates the proliferation,invasion,metastasis and apoptosis of cancer cells by acting on different target genes in different tumors,showing either oncogenic or pro-oncogenic effects.This article reviews the important biological functions and related mechanisms of miR-324-5p in malignant tumors,aiming to provide new ideas for the development of malignant tumor-related markers and effective therapeutic targets.关键词
微小RNA-324-5p/恶性肿瘤/机制/生物标志物/综述Key words
MicroRNA-324-5p/Malignant tumor/Mechanism/Biomarkers/Review分类
医药卫生引用本文复制引用
杨清诚,刘晓华..微小RNA-324-5p在恶性肿瘤中的作用及其机制研究进展[J].现代医药卫生,2024,40(16):2813-2819,7.基金项目
"十三五"国家重点研发计划项目(2017YFC0211603). （2017YFC0211603）
