现代医药卫生2024，Vol.40Issue(16)：2820-2825,6.DOI:10.3969/j.issn.1009-5519.2024.16.026
血脑屏障结构与功能及缺血性中风损伤机制的研究进展
Research progress on the structure and function of blood-brain barrier and injury mechanism mechanism of ischemic stroke
摘要
Abstract
Stroke is the disease with high morbidity,disability and mortality worldwide.The blood-brain barrier(BBB)is an important functional structure that maintains the stability of the microenvironment in the brain,and is disrupted in the early stages of stroke,which is a major complication of stroke and exacer-bates the damage to brain tissue caused by stroke.At the same time,the degree of structural and functional in-tegrity of the BBB is a key predictor of the risk of hemorrhagic transformation after thrombolytic therapy and thrombectomy after stroke,and an important therapeutic target for preventing further brain damage in acute stroke.This article reviews the relevant studies on BBB structure,function,ischemic injury changes,and po-tential therapeutic targets in recent years to provide ideas for further knowledge and understanding of ischemic stroke BBB changes and protective drug development.This article reviews the relevant studies on BBB struc-ture,function,ischemic injury changes and potential therapeutic targets in recent years to provide ideas for fur-ther knowledge and understanding of BBB changes in ischemic stroke and protective drugs development.关键词
缺血性中风/血脑屏障/脑微血管内皮细胞/紧密连接/神经炎症/综述Key words
Ischemic stroke/Blood-brain barrier/Brain microvascular endothelial cells/Tight junctions/Neuroinflammation/Review分类
医药卫生引用本文复制引用
谭娇,苏湲淇,徐晓玉,薛强..血脑屏障结构与功能及缺血性中风损伤机制的研究进展[J].现代医药卫生,2024,40(16):2820-2825,6.基金项目
国家自然科学基金面上项目(81473549) （81473549）
国家科技重大新药创制专项(2014ZX09304-306-04) （2014ZX09304-306-04）
重庆市自然科学基金项目(cstc2018jcyjA0749). （cstc2018jcyjA0749）
