现代医药卫生2024，Vol.40Issue(16)：2841-2845,5.DOI:10.3969/j.issn.1009-5519.2024.16.030
外泌体介导巨噬细胞极化调控肝细胞癌肿瘤微环境的研究进展
Progress of exosome-mediated macrophage polarisation in regulating the tumour microenvironment in hepatocellular carcinoma
摘要
Abstract
Macrophages,as one of infiltrating immune cells,are closely related to the tumour microen-vironment(TME),and they possess remarkable plasticity,transforming into phenotypes with opposite effects under different stimuli.Exosomes as carriers of biological information,are rich in activity and can fulfil the mutual communication between cells.Studies have shown that cancer cell-derived exosomes can carry biologi-cal information from source cells to regulate macrophage function and influence the TME by mediating macro-phage polarisation,which in turn affects tumour progression.Hepatocellular carcinoma(HCC)-associated macrophages are a group of macrophages existing in the tumour immune microenvironment,influencing vari-ous malignant behaviours of hepatocellular carcinoma cells and the immune escape state within the tumour,which in turn affects the progression of hepatocellular carcinoma.In this paper,we reviewed the role of exo-some-mediated macrophage polarisation in the TME of hepatocellular carcinoma to provide new directions for the treatment of hepatocellular carcinoma.关键词
外泌体/巨噬细胞/肿瘤微环境/肝细胞癌/综述Key words
Exosome/Macrophages/Tumor microenvironment/Hepatocellular carcinoma/Review分类
医药卫生引用本文复制引用
周虹江,谢喜科,贺娟,叶宇璐,杨宛林,易廷庄..外泌体介导巨噬细胞极化调控肝细胞癌肿瘤微环境的研究进展[J].现代医药卫生,2024,40(16):2841-2845,5.基金项目
广西壮族自治区自然科学基金项目(GXNSFAA297170). （GXNSFAA297170）
