现代医药卫生2024，Vol.40Issue(16)：2855-2858,2872,5.DOI:10.3969/j.issn.1009-5519.2024.16.033
老年衰弱发病机制的研究进展
Research progress on the pathogenesis of geriatric frailty
摘要
Abstract
Geriatric frailty is a complex syndrome faced by the elderly,which is characterized by the de-crease of physiological reserve and imbalance of multiple organ systems,which leads to the decrease of self-stability ability,the weakening of daily activity ability and the decline of quality of life.With the aging of the population,frailty is gradually becoming a public health problem that threatens the health of the elderly,seri-ously affecting the quality of life and clinical outcomes of the elderly.The pathogenesis of geriatric frailty is a complex process,including inflammatory response,cell senescence,intestinal flora disorder,insulin resistance,neuroendocrine disorders and other effects.This article reviews the pathogenesis of frailty in the elderly,and provides clues and basis for identifying risk factors for frailty,formulating corresponding prevention and inter-vention strategies,delaying frailty in the elderly,and improving the quality of life of the elderly.关键词
老年衰弱/细胞衰老/肠道菌群/胰岛素抵抗/神经内分泌激素/综述Key words
Geriatric frailty/Cell senescence/Intestinal flora/Insulin resistance/Neuroendo-crine hormones/Review分类
医药卫生引用本文复制引用
曾炜,管张烁,沈大鹏,沈洁淼..老年衰弱发病机制的研究进展[J].现代医药卫生,2024,40(16):2855-2858,2872,5.基金项目
江苏省高等学校大学生创新创业训练计划项目(202310312074Y). （202310312074Y）
