眼科学报2024，Vol.39Issue(5)：234-245,12.DOI:10.12419/24022208
预测儿童Ⅱ期人工晶状体植入术后青光眼相关不良事件的风险:一项为期3年的研究
Predicting the risk of glaucoma-related adverse events following secondary intraocular lens implantation in paediatric eyes:a 3-year study
摘要
Abstract
Aims:To establish and evaluate predictive models for glaucoma-related adverse events(GRAEs)following secondary intraocular lens(IOL)implantation in paediatric eyes.Methods:205 children(356 aphakic eyes)receiving secondary IOL implantation at Zhongshan Ophthalmic Center with a 3-year follow-up were enrolled.Cox proportional hazard model was used to identify predictors of GRAEs and developed nomograms.Model performance was evaluated with time-dependent receiver operating characteristic(ROC)curves,decision curve analysis,Kaplan-Meier curves and validated internally through C-statistics and calibration plot of the bootstrap samples.Results:Older age at secondary IOL implantation(HR=1.5,95%CI:1.03 to 2.19),transient intraocular hypertension(HR=9.06,95%CI:2.97 to 27.67)and ciliary sulcus implantation(HR=14.55,95%CI:2.11 to 100.57)were identified as risk factors for GRAEs(all p<0.05).Two nomograms were established.At postoperatively 1,2 and 3 years,model 1 achieved area under the ROC curves(AUCs)of 0.747(95%CI:0.776 to 0.935),0.765(95%CI:0.804 to 0.936)and 0.748(95%CI:0.736 to 0.918),and the AUCs of model 2 were 0.881(95%CI:0.836 to 0.926),0.895(95%CI:0.852 to 0.938)and 0.848(95%CI:0.752 to 0.945).Both models demonstrated fine clinical net benefit and performance in the interval validation.The Kaplan-Meier curves showing two distinct risk groups were well discriminated and robust in both models.An online risk calculator was constructed.Conclusions:Two nomograms could sensitively and accurately identify children at high risk of GRAEs after secondary IOL implantation to help early identification and timely intervention.关键词
儿童健康(儿科)/青光眼/晶状体和悬韧带/视力Key words
Child health(paediatrics)/Glaucoma/Lens and zonules/Vision分类
医药卫生引用本文复制引用
Hui Chen,Weirong Chen,Danying Zheng,Yizhi Liu,Zhenzhen Liu,《眼科学报》出版团队,金佳昕,陈子东,Chaoqun Xu,Ling Jin,Zhenyu Wang,Jingmin Xu,Yingshi Zou,Guangming Jin,Lixia Luo,Haotian Lin..预测儿童Ⅱ期人工晶状体植入术后青光眼相关不良事件的风险:一项为期3年的研究[J].眼科学报,2024,39(5):234-245,12.基金项目
广州市科技计划(202201011815).This work was supported by the Science and Technology Program of Guangzhou,China,(202201011815). （202201011815）
