从基因层面揭示户外活动与近视的因果关系:基于孟德尔随机化原理OA
Revealing the causal relationship between outdoor activities and myopia from genetic level:based on Mendelian randomization
目的:运用孟德尔随机化(Mendelian randomization,MR)方法,探索户外活动与近视之间的双向因果关系.方法:来自英国生物银行(UK Biobank)的大型队列研究数据,选择与欧洲血统人群中户外活动与近视相关的相互独立的遗传位点作为IV.户外活动的全基因组关联研究(genome-wide association study,GWAS)数据包含419 314名欧洲人群,而近视的GWAS数据则包含460 536名欧洲人群,其中37 …查看全部>>
Objective:To employ Mendelian randomization(MR)methods to explore bidirectional causal relationships between outdoor activities and myopia.Methods:Large-scale cohort study data from the UK Biobank were utilized,selecting independent genetic loci associated with outdoor activities and myopia within the European ancestry population as instrumental variables.The outdoor activities GWAS data included 419,314 individuals of European descent,while the myopia GWAS …查看全部>>
魏熙翔;杨晖
厦门市儿童医院,复旦大学附属儿科医院厦门医院,厦门 361006厦门市儿童医院,复旦大学附属儿科医院厦门医院,厦门 361006
临床医学
因果关系孟德尔随机化户外活动近视
causal relationshipMendelian randomizationoutdoorsmyopia
《眼科学报》 2024 (5)
246-258,13
厦门市医疗卫生项目(指导性项目)(3502Z20214ZD1240)厦门市医工结合指导性项目(3502Z20244ZD2058).This work was supported by Medical and Health Project of Xiamen Guidance Project(3502Z20214ZD1240)and Xiamen Medical and Engineering Integration Guidance Project(3502Z20244ZD2058).
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