中风与神经疾病杂志2024，Vol.41Issue(8)：686-691,6.DOI:10.19845/j.cnki.zfysjjbzz.2024.0132
乳脂球表皮生长因子8与阿尔茨海默病的关联
Association between milk fat globule-epidermal growth factor 8 with Alzheimer disease
摘要
Abstract
Objective To investigate the association between milk fat globule-epidermal growth factor 8(MFG-E8)and Alzheimer disease(AD).Methods The Alzheimer's Disease Neuroimaging Initiative database was used,and a multiple linear regression analysis was used to investigate the association of MFG-E8 with the pathological markers of AD and brain structure and perform subgroup analyses.The mixed-effects model was used to investigate the longitudinal changes in MFG-E8 with AD pathological markers and brain structure,and a mediation analysis was used to investigate the potential association of MFG-E8 with AD pathology and brain structure.Results A total of 377 individuals were en-rolled in the study.The level of MFG-E8 was positively correlated with the concentrations of amyloid β-protein 42(Aβ42),tau protein,and phosphorylated tau protein in cerebrospinal fluid,and subgroup analyses showed that the correlation of MFG-E8 with the concentrations of AD pathological markers and lateral ventricular volume in male individuals,the elderly popula-tion,and the individuals carrying the APOE4 gene was consistent with that in the overall population.Longitudinal studies showed that during follow-up,the increase in MFG-E8 level was significantly associated with enlarged lateral ventricle volume.In addition,MFG-E8 could alter lateral ventricle volume by affecting the level of Aβ42.Conclusion MFG-E8 is associated with AD and may influence lateral ventricular volume through AD pathological markers.关键词
乳脂球表皮生长因子8/阿尔茨海默病/痴呆/β淀粉样蛋白42Key words
Milk fat globule-epidermal growth factor 8/Alzheimer disease/Dementia/Amyloid β-protein 42分类
医药卫生引用本文复制引用
张子豪,朱阳可,王誉静,马灵志,谭兰..乳脂球表皮生长因子8与阿尔茨海默病的关联[J].中风与神经疾病杂志,2024,41(8):686-691,6.基金项目
国家自然科学基金(82271475,82201587) （82271475,82201587）
