中风与神经疾病杂志2024，Vol.41Issue(8)：709-713,5.DOI:10.19845/j.cnki.zfysjjbzz.2024.0136
低强度聚焦超声活化小胶质细胞治疗阿尔茨海默病的动物研究进展
Advances in animal studies on the activation of microglial cells by low-intensity focused ultrasound in treatment of Alzheimer disease
摘要
Abstract
Alzheimer disease is a common neurodegenerative disease among the elderly and has abnormal accumula-tion of amyloid plaques as the typical pathological feature.Because of its strict selective permeability,the blood-brain bar-rier prevents all macromolecular substances from entering the central nervous system and has thus become a"bottleneck"for delivering therapeutic drugs to the brain.Studies have shown that low-intensity focused ultrasound combined with ultra-sound microbubbles can safely and reversibly open the junction between endothelial cells of the blood-brain barrier through cavitation and reduce amyloid deposition by promoting the activation of microglial cells into an anti-inflammatory state.This article reviews the latest research advances in low-intensity focused ultrasound in the treatment of Alzheimer disease,in order to provide a theoretical basis and new strategies for the treatment of Alzheimer disease.关键词
阿尔茨海默病/低强度聚焦超声/小胶质细胞/血脑屏障Key words
Alzheimer disease/Low-intensity focused ultrasound/Microglial cell/Blood-brain barrier分类
医药卫生引用本文复制引用
李硕,刘焕亮,崔慧娟,曹慧,付源..低强度聚焦超声活化小胶质细胞治疗阿尔茨海默病的动物研究进展[J].中风与神经疾病杂志,2024,41(8):709-713,5.基金项目
黑龙江省自然科学基金联合引导项目(LH2021H036) （LH2021H036）
国家自然科学基金(81500917) （81500917）
教育部"春晖计划"合作科研项目(HLJ2019012) （HLJ2019012）
黑龙江省博士后科研启动基金(LBH-Q19033) （LBH-Q19033）
黑龙江省留学归国科学基金(LC2016033) （LC2016033）
哈尔滨医科大学伍连德青年科学基金(WLD-QN1711) （WLD-QN1711）
浙江大学百人计划启动基金(B202306) （B202306）
