中风与神经疾病杂志2024，Vol.41Issue(8)：714-717,4.DOI:10.19845/j.cnki.zfysjjbzz.2024.0137
线粒体功能障碍在阿尔茨海默病铁死亡中的作用研究进展
Research advances in the role of mitochondrial dysfunction in ferroptosis in Alzheimer disease
摘要
Abstract
Ferroptosis is a novel type of oxidatively regulated cell death driven by iron-dependent lipid peroxidation.As the main site of iron utilization and oxidative metabolism,mitochondria are the main source of intracellular reactive oxy-gen species.Ferroptosis is associated with the severe impairment of mitochondrial structure and function,bioenergetics,and metabolism.Alzheimer disease(AD)is a devastating progressive neurodegenerative disease with the main clinical manifestation of decline in memory and cognitive function.Emerging evidence suggests that mitochondrial dysfunction plays a significant role in the process of ferroptosis in AD.This article elaborates on the mechanism of ferroptosis,mito-chondrial dysfunction and its role in ferroptosis in AD,and the treatment of AD,in order to provide a new perspective for exploring new strategies for the prevention and treatment of AD.关键词
铁死亡/线粒体/阿尔茨海默病/治疗Key words
Ferroptosis/Mitochondria/Alzheimer disease/Treatment分类
医药卫生引用本文复制引用
武会敏,武园梅,葛朝明..线粒体功能障碍在阿尔茨海默病铁死亡中的作用研究进展[J].中风与神经疾病杂志,2024,41(8):714-717,4.基金项目
甘肃省神经内科临床医学研究中心资助项目(20JR10FA663) （20JR10FA663）
