中国感染控制杂志2024，Vol.23Issue(8)：932-941,10.DOI:10.12138/j.issn.1671-9638.20245427
湖南省细菌耐药监测网2012-2021年脑脊液标本分离细菌耐药性监测报告
Antimicrobial resistance of bacteria from cerebrospinal fluid specimens:surveillance report from Hunan Province Antimicrobial Resistance Survei-llance System,2012-2021
刘君 1袁红霞 2郑铭 3任南 4吴安华 4黄勋 4唐曼娟 1陈丽华 5付陈超 3李晨 6李艳明 7宁兴旺 8石国民 9邬靖敏 10杨怀德11
作者信息
- 1. 湘潭市中心医院检验科,湖南 湘潭 411100
- 2. 郴州市第一人民医院检验医学中心,湖南 郴州 423000
- 3. 中南大学湘雅医院医院感染控制中心,湖南 长沙 410008||湖南省细菌耐药监测网办公室,湖南 长沙 410008
- 4. 中南大学湘雅医院医院感染控制中心,湖南 长沙 410008||湖南省细菌耐药监测网办公室,湖南 长沙 410008||湖南省医院感染管理质量控制中心,湖南长沙 410008||国家老年疾病临床医学研究中心(湘雅医院),湖南长沙 410008
- 5. 中南大学湘雅三医院检验科,湖南 长沙 410013
- 6. 浏阳市中医医院检验科,湖南浏阳 410300
- 7. 中南大学湘雅医院检验科,湖南 长沙 410008
- 8. 湖南中医药大学第一附属医院医学检验与病理中心,湖南长沙 410011
- 9. 长沙市中心医院检验科,湖南 长沙 410004
- 10. 长沙市第一医院检验科,湖南 长沙 410005
- 11. 张家界市人民医院检验科,湖南 张家界 427000
- 折叠
摘要
Abstract
Objective To investigate changes in the distribution and antimicrobial resistance of bacteria isolated from cerebrospinal fluid(CSF)specimens in Hunan Province,and provide reference for correct clinical diagnosis and rational antimicrobial use.Methods Data reported by member units of Hunan Province Antimicrobial Resistance Surveillance System from 2012 to 2021 were collected according to China Antimicrobial Resistance Surveillance Sys-tem(CARSS)technical scheme.Data of bacteria isolated from CSF specimens and antimicrobial susceptibility tes-ting results were analyzed with WHONET 5.6 and SPSS 20.0 software.Results A total of 11 837 bacterial strains were isolated from CSF specimens from member units of Hunan Province Antimicrobial Resistance Surveillance Sys-tem from 2012 to 2021.The top 5 strains were coagulase-negative Staphylococcus(n=6 397,54.0％),Acineto-bacter baumannii(n=764,6.5％),Staphylococcus aureus(n=606,5.1％),Enterococcus faecium(n=465,3.9％),and Escherichia coli(n=447,3.8％).The detection rates of methicillin-resistant coagulase-negative Staphyloco-ccus(MRCNS)and methicillin-resistant Staphylococcus aureus(MRSA)were 58.9％-66.3％and 34.4％-62.1％,respectively.No Staphylococcus spp.were found to be resistant to vancomycin,linezolid,and teicoplanin.The de-tection rate of Enterococcus faecium was higher than that of Enterococcus faecalis,and the resistance rates of En-terococcus f aecium to penicillin,ampicillin,high concentration streptomycin and levofloxacin were all higher than those of Enterococcus faecalis(all P=0.001).Resistance rate of Streptococcus pneumoniae to penicillin was 85.0％,at a high level.Resistance rate of Escherichia coli to ceftriaxone was＞60％,while resistance rates to enzyme inhibitors and carbapenem antibiotics were low.Resistance rate of Klebsiella pneumoniae to ceftriaxone was＞60％,to en-zyme inhibitors piperacillin/tazobactam and cefoperazone/sulbactam was＞30％,to carbapenem imipenem and me-ropenem was about 30％.Resistance rates of Acinetobacter baumannii to most tested antimicrobial agents were＞60％,to imipenem and meropenem were 59.0％-79.4％,to polymyxin B was low.Conclusion Among the bac-teria isolated from CSF specimens,coagulase-negative Staphylococcus accounts for the largest proportion,and the overall resistance of pathogenic bacteria is relatively serious.Bacterial antimicrobial resistance surveillance is very important for the effective treatment of central nerve system infection.关键词
脑脊液/病原菌/耐药性/凝固酶阴性葡萄球菌/鲍曼不动杆菌/湖南省细菌耐药监测网Key words
cerebrospinal fluid/pathogen/antimicrobial resistance/coagulase-negative Staphylococcus/Acineto-bacter baumannii/Hunan Province Antimicrobial Resistance Surveillance system分类
医药卫生引用本文复制引用
刘君,袁红霞,郑铭,任南,吴安华,黄勋,唐曼娟,陈丽华,付陈超,李晨,李艳明,宁兴旺,石国民,邬靖敏,杨怀德..湖南省细菌耐药监测网2012-2021年脑脊液标本分离细菌耐药性监测报告[J].中国感染控制杂志,2024,23(8):932-941,10.
