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湖南省细菌耐药监测网2012-2021年肠球菌属细菌耐药性监测报告

付陈超袁红霞郑铭吴安华黄勋任南陈丽华李晨李艳明刘君宁兴旺石国民邬靖敏杨怀德

中国感染控制杂志2024，Vol.23Issue(8)：954-962,9.

中国感染控制杂志2024，Vol.23Issue(8)：954-962,9.DOI:10.12138/j.issn.1671-9638.20245432

湖南省细菌耐药监测网2012-2021年肠球菌属细菌耐药性监测报告

Antimicrobial resistance of Enterococcus spp.:surveillance report from Hunan Province Antimicrobial Resistance Surveillance System,2012-2021

付陈超 ¹袁红霞 ²郑铭 ¹吴安华 ³黄勋 ³任南 ³陈丽华 ⁴李晨 ⁵李艳明 ⁶刘君 ⁷宁兴旺 ⁸石国民 ⁹邬靖敏 ¹⁰杨怀德¹¹

作者信息

1. 中南大学湘雅医院医院感染控制中心,湖南长沙 410008||湖南省细菌耐药监测网办公室,湖南长沙 410008
2. 郴州市第一人民医院检验医学中心,湖南郴州 423000
3. 中南大学湘雅医院医院感染控制中心,湖南长沙 410008||湖南省细菌耐药监测网办公室,湖南长沙 410008||湖南省医院感染管理质量控制中心,湖南长沙 410008||国家老年疾病临床医学研究中心(湘雅医院),湖南长沙 410008
4. 中南大学湘雅三医院检验科,湖南长沙 410013
5. 浏阳市中医医院检验科,湖南浏阳 410300
6. 中南大学湘雅医院检验科,湖南长沙 410008
7. 湘潭市中心医院检验科,湖南湘潭 411100
8. 湖南中医药大学第一附属医院医学检验与病理中心,湖南长沙 410011
9. 长沙市中心医院检验科,湖南长沙 410004
10. 长沙市第一医院检验科,湖南长沙 410005
11. 张家界市人民医院检验科,湖南张家界 427000
折叠

摘要

Abstract

Objective To understand the antimicrobial resistance of clinically isolated Enterococcus spp.in Hunan Province.Methods Surveillance data of Enterococcus spp.resistance from member units of Hunan Provincial Anti-microbial Resistance Surveillance System from 2012 to 2021 were collected.Data were cleaned according to a unified method,and WHONET 5.6 software was adopted for statistical analysis.Results From 2012 to 2021,a total of 110 652 non-repetitive Enterococcus spp.strains were included in the analysis,mainly Enterococcus faecalis and Enterococcus faecium,accounting for 46.9％(n=37 774)and 45.9％(n=36 968),respectively,followed by En-terococcus avium(2.5％,n=1 982),Enterococcus gallinarum(1.8％,n=1 428),and Enterococcus casseliflavus(1.5％,n=1 185).The main specimen sources of Enterococcus spp.was urine(51.8％,n=57 350),followed by secretions(9.6％,n=10 660)and bile(8.5％,n=9 377).From 2012 to 2021,the resistance rates of Enteroco-ccus faecalis to ampicillin,teicoplanin,and vancomycin were 5.5％-12.0％,1.3％-2.0％,and 0.6％-1.4％,respectively.The resistance rates of Enterococcus faecium to ampicillin,teicoplanin,and vancomycin were 69.2％-85.0％,1.5％-2.8％,and 0.7％-2.5％,respectively.Except for linezolid and minocycline,the resistance rates of Enterococcus faecium to tested antimicrobial agents were all higher than those of Enterococcus faecalis.The re-sistance rates of Enterococcus faecalis and Enterococcus faecium to vancomycin decreased from 1.4％and 2.1％in 2012 to 0.6％and 0.7％in 2021,respectively,presenting a decreased trend.Conclusion Clinically isolated En-terococcus spp.maintain high antimicrobial susceptibility to vancomycin and teicoplanin.Resistance rates of Entero-coccus faecalis and Enterococcus faecium to vancomycin present decreased trends.

关键词

肠球菌属/细菌耐药性监测/耐药性变迁/抗菌药物/湖南省细菌耐药监测网

Key words

Enterococcus spp./bacterial resistance surveillance/change in antimicrobial resistance/antimicrobial agent/Hunan Provincial Antimicrobial Resistance Surveillance System

分类

医药卫生

引用本文复制引用

付陈超,袁红霞,郑铭,吴安华,黄勋,任南,陈丽华,李晨,李艳明,刘君,宁兴旺,石国民,邬靖敏,杨怀德..湖南省细菌耐药监测网2012-2021年肠球菌属细菌耐药性监测报告[J].中国感染控制杂志,2024,23(8):954-962,9.

基金项目

湖南省自然科学基金项目(2021JJ40980) （2021JJ40980）

"感·动中国"医疗机构感染预防与控制科研项目(GY2023013-A) （GY2023013-A）

中国感染控制杂志

OA北大核心CSTPCD

ISSN：1671-9638

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