中国药房2024，Vol.35Issue(16)：2009-2012,4.DOI:10.6039/j.issn.1001-0408.2024.16.12
西曲瑞克联合阿司匹林预防早发型卵巢过度刺激综合征的疗效观察
Efficacy observation of cetrorelix combined with aspirin in preventing early-onset ovarian hyperstimulation syndrome
摘要
Abstract
OBJECTIVE To observe the efficacy of cetrorelix combined with aspirin in preventing early-onset ovarian hyperstimulation syndrome(OHSS).METHODS A retrospective analysis was conducted on clinical data from 38 early-onset OHSS patients,who received treatment in our hospital from January 1st to July 1st,2022.These patients were divided into intervention group(19 cases)and control group(19 cases)according to the therapy regimen.On the first day after oocyte retrieval surgery,the control group was given aspirin enteric-coated tablets 100 mg orally until menstruation began.The intervention group was given cetrorelix for injection 0.25 mg subcutaneously,for consecutive 3 days+aspirin enteric-coated tablets(same usage and dosage as the control group).The first luteal phase,the degree of OHSS,and the ovarian volume,ascites volume,serum estradiol(E2),white blood cell count(WBC),hematocrit(HCT),neutrophil ratio(NEUT%),D-dimer(DD),prothrombin time(PT),fibrinogen(Fib)after oocyte retrieval surgery were observed and measured in 2 groups.RESULTS The first luteal phase was significantly shorter,and the proportions of median and severe OHSS cases were significantly lower in the intervention group compared to the control group(P＜0.05 or P＜0.01).After oocyte retrieval surgery,the intervention group showed significantly lower ovarian volume,ascites volume,serum E2,WBC,NEUT%,HCT,DD and Fib compared to the control group,but PT of intervention group was signiticantly higher than that of control group(P＜0.05).CONCLUSIONS Cetrorelix combined with aspirin is more effective in preventing early-onset OHSS than aspirin alone.关键词
卵巢过度刺激综合征/西曲瑞克/阿司匹林/卵泡期长效长方案/促排卵Key words
ovarian hyperstimulation syndrome/cetrorelix/aspirin/long-lasting follicular phase protocol/ovulation induction分类
医药卫生引用本文复制引用
张莹莹,张轶乐,史昊,卜志勤,杨丽,孟艳蕾,郭艺红..西曲瑞克联合阿司匹林预防早发型卵巢过度刺激综合征的疗效观察[J].中国药房,2024,35(16):2009-2012,4.基金项目
国家自然科学基金项目(No.32271169) （No.32271169）
