中国药房2024，Vol.35Issue(16)：2048-2054,7.DOI:10.6039/j.issn.1001-0408.2024.16.20
活血化瘀类中药通过调控细胞自噬防治心血管疾病的研究进展
Research progress on the prevention and treatment of cardiovascular diseases using traditional Chinese medicine for promoting blood circulation and removing blood stasis by regulating autophagy
摘要
Abstract
Autophagy is mediated by multiple molecules and pathways.In cardiovascular diseases,autophagy can play a role through key signaling pathways such as phosphoinositide 3-kinase(PI3K)/protein kinase B(Akt)/mammalian target of rapamycin(mTOR),adenosine monophosphate-activated protein kinase(AMPK)/mTOR,mitogen-activated protein kinases(MAPK),p53,Wnt/β-catenin,etc.Traditional Chinese medicine(TCM)monomers for promoting blood circulation and removing blood stasis such as hydroxysafflor yellow A,ginsenoside Rb1,salidroside,ligustrin,curcumin,etc.,and TCM prescription and preparations such as Huangqi baoxin decoction,Taohong siwu decoction,Tongxinluo capsule,Shuangshen ningxin capsule,Suxiao jiuxin pills,etc.can regulate autophagy through the above-mentioned key signaling pathways,thereby alleviating the progression of cardiovascular diseases.关键词
细胞自噬/中药/活血化瘀/心血管疾病Key words
autophagy/traditional Chinese medicine/promoting blood circulation and removing blood stasis/cardiovascular disease分类
医药卫生引用本文复制引用
孙鑫,梁霄,李娅兰,肖展,文武龙,张炜烨,杨婧,王锐..活血化瘀类中药通过调控细胞自噬防治心血管疾病的研究进展[J].中国药房,2024,35(16):2048-2054,7.基金项目
国家自然科学基金项目(No.82074271) （No.82074271）
