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5种治疗胸痹心痛中成药临床综合评价OA

Clinical Comprehensive Evaluation of Five Kinds of Chinese Patent Medicines in the Treatment of Chest Stuffiness and Pains

中文摘要英文摘要

目的 对治疗胸痹心痛的中成药展开临床综合评价,以期为治疗胸痹心痛的临床药物选择及卫生部门决策提供参考.方法 通过系统评价、网状Meta分析评价 5 种中成药的安全性、有效性.以有效性评价结果为依据,采用成本-效果分析评价经济性.同时在国家药品监督管理局(NMPA)、国家卫生健康委员会等网站广泛搜集现存统计资料进行适宜性、可及性和创新性的评价.结果 从有效性看,5 种中成药之间总有效率并无明显差距;从安全性看,救心丸不良反应信息收集完备,相对更优;从经济性看,在短期药物经济学评价视角下救心丸价格最低,经济性最佳;从适宜性看,救心丸服用方式便捷、存储条件简单且限制少;从可及性看,愈风宁心滴丸覆盖面积相对较大,而救心丸负担较轻;从创新性方面看,中成药治疗胸痹心痛具有一定的创新性,主要集中于药品制备和检测环节,具有开发的潜力与价值.结论 化瘀宽胸型中成药在临床胸痹心痛的治疗中应用广泛,且具有较好的疗效和安全性,具有一定的临床应用价值.

Objective To carry out a clinical comprehensive evaluation of traditional Chinese patent medicines in the treatment of chest stuffiness and pains,so as to provide a reference for clinical drug selection and health department decision-making.Methods The safety and effectiveness of five traditional Chinese patent medicines were evaluated by Systematic Reviews and network Meta-analysis.Based on the effectiveness evaluation results,cost-effectiveness analysis is applied to the economic evaluation.At the same time,existing statistical data is widely collected on websites such as NMPA and the National Health Commission of the People's Republic of China for suitability,accessibility,and innovative evaluation.Results For effectiveness,there was no significant difference in the total effective rate among the five traditional Chinese patent medicines.For safety,the collection of adverse reaction information of Jiuxin Pills is complete and relatively superior.For economy,the Jiuxin Pills have the lowest price and the best economic performance resulted from the cost-minimization analysis.For suitability,the utilization of Jiuxin Pills is convenient,the storage conditions are simple,and there are few restrictions.For accessibility,the coverage area of Yufeng Ningxin Dropping Pills is relatively large and the treatment burden of Jiuxin Pills is relatively light.For innovation,traditional Chinese patent medicines have certain innovation in treating chest pain,mainly focusing on drug manufacturing and testing,with potential and value for development.Conclusion The removing blood stasis and widening chest traditional Chinese patent medicines have been widely used in the treatment of chest stuffiness and pains,who has good effectiveness,safety,and certain clinical value.

孙阳;许文航;梁伟春;周乃彤

四川大学华西药学院,成都 610000北京华氏康源医药科技有限公司,北京 100000

中医学

中成药胸痹心痛临床综合评价

Chinese patent medicinesChest stuffiness and painsClinical comprehensive evaluation

《中国药物经济学》 2024 (008)

5-13,17 / 10

10.12010/j.issn.1673-5846.2024.08.001

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