中性粒细胞/淋巴细胞比值及单核细胞/淋巴细胞比值预测泊马度胺为基础方案治疗复发难治多发性骨髓瘤疗效的价值OA

Objective To investigate the value of peripheral blood neutrophil/lymphocyte ratio(NLR)and monocyte/lymphocyte ratio(MLR)in predicting the efficacy of pomalidomide based regimen in the treatment of relapsed refractory multiple myeloma(RRMM).Methods Thirty-seven RRMM patients who received pomadomidum-based regimen in Heze Municipal Hospital from March 2021 to March 2023 were selected as the observation group,and 40 healthy subjects during the same period were selected as the control group.The levels of peripheral blood NLR and MLR were compared between the two groups and the correlation between the levels of peripheral blood NLR and MLR and the therapeutic effect of patients with different therapeutic effects in the observation group,and the predictive value of peripheral blood NLR and MLR on the therapeutic effect of pomalidomide based regimen was analyzed.Results After treatment,the levels of NLR and MLR in peripheral blood of the observation group were significantly lower than before treatment,and the levels of NLR and MLR in peripheral blood of the observation group were significantly higher than those of the control group before and after treatment,with statistical significance(P＜0.05).Observation group after treatment,5 cases complete remission,14 cases partial remission,8 cases mild remission,10 cases ineffective.The levels of peripheral blood NLR and MLR in complete remission group were the lowest,followed by partial remission group and mild remission group,and the highest in ineffective group.There were statistically significant differences in peripheral blood NLR and MLR levels among the four groups(P＜0.05).The levels of NLR and MLR in peripheral blood were positively correlated with the therapeutic effect of pomalidomide based regimen(P＜0.001).According to receiver operating characteristic curve(ROC)analysis,the area under the predicted curve(AUC)of peripheral blood NLR was 0.753,P=0.005,sensitivity was 81.5%,specificity was 64.7%,95%CI was 0.597～0.909.The predicted AUC for peripheral blood MLR after treatment was 0.735,P=0.009,sensitivity 85.2%,specificity 64.7%,95%CI 0.563～0.908.Conclusion Peripheral blood NLR and MLR levels play an important role in predicting the effect of pomeradomidum-based regimen in the treatment of RRMM,and the significant reduction of peripheral blood NLR and MLR levels after treatment indicates that the treatment effect is better.