摘要
Abstract
Objective To explore the effect of daglizin on clinical efficacy,blood glucose control and cardiac function in patients with diabetes mellitus complicated with heart failure.Methods A total of 74 patients with diabetes mellitus and heart failure admitted to Jiangmen Central Hospital from January 2022 to February 2023 were selected as the study objects,and were divided into control group and observation group according to random number table method,with 37 cases in each group.Patients with heart failure were given symptomatic treatment with angiotensin inhibitors,diuretics and β-blockers,the control group was given metformin hydrochloride tablets on the basis of this,and the observation group was treated with dagliaglozin.The clinical efficacy,blood glucose control,cardiac function,vascular endothelial growth factor(VEGF)and adverse reactions were compared between the two groups.Results The effective rate of observation group was 97.30%,which was higher than that of control group(81.08%)(P＜0.05).Fasting blood glucose,2 h postprandial blood glucose and glycated hemoglobin in the two groups after treatment were lower than before treatment(P＜0.05),but there was no statistical significance between the two groups(P＞0.05).After treatment,stroke output(SV)and left ventricular ejection fraction(LVEF)in 2 groups were higher than before treatment,and observation group was higher than control group,and left ventricular end-diastolic diameter(LVEDD)in 2 groups was lower than before treatment,and observation group was lower than control group,the difference was statistically significant(P＜0.05).After treatment,VEGF levels in the two groups were lower than before treatment,and the observation group was lower than the control group,the difference was statistically significant(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Daglipzin can effectively improve the clinical efficacy and cardiac function in patients with diabetes mellitus complicated with heart failure,and its mechanism may be related to the reduction of VEGF levels.关键词
达格列净/糖尿病/心力衰竭/血管内皮生长因子Key words
Dagliflozin/Diabetes mellitus/Heart failure/Vascular endothelial growth factor分类
医药卫生
