中国医学装备2024，Vol.21Issue(8)：75-79,95,6.DOI:10.3969/j.issn.1672-8270.2024.08.014
高频超声评估肱动脉血流介导的血管舒张功能联合血清磷脂酰丝氨酸1磷酸盐预测脓毒症患者血管内皮功能的研究
Study on the brachial artery FMD function with high-frequency ultrasound assessment combined with S1P in predicting vascular endothelial function of patients with sepsis
摘要
Abstract
Objective:To explore the value of flow-mediated vasodilation(FMD)of brachial artery,which was assessed by high-frequency ultrasound assessment,combined with serum phosphatidylserine 1 phosphate(S1P)levels in predicting vascular endothelial function of patients with sepsis.Methods:A total of 140 patients with sepsis who admitted to the People's Hospital of Nanchuan Chongqing from February 2021 to February 2023 were selected as the case group,and 140 volunteers who underwent health physical examinations in the hospital during the same period were selected as the healthy control group.High-frequency ultrasound was used to measure the brachial artery FMD of the two groups,and the serum S1P levels of the two groups were also detected.The correlation between FMD,S1P and vascular endothelial function in patients with sepsis was analyzed,as well as the diagnostic performances of FMD and S1P in assessing vascular endothelial function of patients with sepsis.And then,the correlation between FMD,S1P levels and the vascular endothelial function score(VEFS)in patients with sepsis was further analyzed.Results:The FMD(4.21±1.63),S1P(0.82±0.24)and VEFS(0.42±0.15)levels in the case group were significantly lower than those(7.35±2.15,1.28±0.32,0.78±0.18)in the healthy control group(t=-14.23,-13.56,-17.32,P<0.05),respectively.The FMD and S1P levels were significantly positive correlation with VEFS in the case group(r=0.62,0.58,P<0.01),and they were significantly negative correlation with C-reactive protein(CRP)(r=-0.55,-0.51,P<0.01),respectively.As single-factor indicators of predicting vascular endothelial function of patients with sepsis,area under curve(AUC)values of receiver operating characteristic(ROC)curves of FMD and S1P levels were respectively 0.83 and 0.82,and the sensitivities of them were respectively 74.0%and 77.0%,specificities of them were respectively 78.0%and 75.0%.As the multi-factor indicator of predicting vascular endothelial function of patients with sepsis,the AUC,sensitivity and specificity of the combination of FMD and S1P levels were respectively 0.90,88.0%and 77.0%.Conclusion:Brachial artery FMD,which is assessed by high-frequency ultrasound,combined with serum S1P levels can effectively predict vascular endothelial function of patients with sepsis,which has important clinical significance in diagnosing and treating patients with sepsis.关键词
高频超声/血流介导的血管舒张功能/肱动脉/磷脂酰丝氨酸1磷酸盐/脓毒症/血管内皮功能Key words
High-frequency ultrasound/Flow-mediated vasodilation(FMD),Brachial artery/Sphingosine-1-Phosphate(S1P)/Sepsis/Vascular endothelial function(VEF)分类
医药卫生引用本文复制引用
田茂伦,肖红,程叶锋..高频超声评估肱动脉血流介导的血管舒张功能联合血清磷脂酰丝氨酸1磷酸盐预测脓毒症患者血管内皮功能的研究[J].中国医学装备,2024,21(8):75-79,95,6.基金项目
重庆市自然科学基金面上项目(cstc2021jcyj-msxmX0857) Chongqing Natural Science Foundation General Project(cstc2021jcyj msxmX0857) （cstc2021jcyj-msxmX0857）
