中国药业2024，Vol.33Issue(16)：109-112,4.DOI:10.3969/j.issn.1006-4931.2024.16.026
宁胃胶囊联合奥美拉唑治疗消化性溃疡临床观察
Clinical Observation of Ningwei Capsules Combined with Omeprazole in the Treatment of Peptic Ulcer
摘要
Abstract
Objective To investigate the clinical efficacy of Ningwei Capsules combined with omeprazole in the treatment of peptic ulcer.Methods A total of 120 patients with peptic ulcer admitted to the hospital from January 2021 to January 2023 were selected and divided into the observation group and the control group by the random number table method,with 60 cases in each group.The patients in the two groups were given oral Omeprazole Enteric Capsules,on this basis,the patients in the observation group were given oral Ningwei Capsules.Both groups were treated continuously for four weeks.Results The total effective rate in the observation group was 95.00%,which was significantly higher than 83.33%in the control group(P<0.05).After treatment,the scores of traditional Chinese medicine(TCM)syndromes(abdominal distension,acid regurgitation,depression,gastric noise,string pulse,chest distress,eating a little)in the two groups significantly decreased,the basal acid output(BAO),maximal acid output(MAO)and peak acid output(PAO)significantly decreased,the serum vascular endothelial growth factor(VEGF)and basic fibroblast growth factor(bFGF)levels significantly increased(P<0.05);and the above indexes in the observation group were significantly better(P<0.05).The incidence of adverse reactions in the observation group was similar to that in the control group(16.67%vs.13.33%,P>0.05).Conclusion Ningwei Capsules combined with omeprazole can effectively improve the TCM symptoms,decrease the gastric acid secretion,and increase the serum VEGF and bFGF levels in patients with peptic ulcer.关键词
宁胃胶囊/奥美拉唑/消化性溃疡/血管内皮生长因子/碱性成纤维细胞生长因子Key words
Ningwei Capsules/omeprazole/peptic ulcer/vascular endothelial growth factor/basic fibroblast growth factor分类
医药卫生引用本文复制引用
杨宇成,袁宇婷,刘海云,张鹏,干定云..宁胃胶囊联合奥美拉唑治疗消化性溃疡临床观察[J].中国药业,2024,33(16):109-112,4.基金项目
湖北省卫生健康委员会科研项目[WJ2021M012]. （）
