中国药业2024，Vol.33Issue(16)：116-119,4.DOI:10.3969/j.issn.1006-4931.2024.16.028
粉尘螨滴剂联合维生素D滴剂辅助治疗儿童哮喘伴过敏性鼻炎临床观察
Clinical Observation of Dermatophagoides Farinae Drops Combined with Vitamin D Drops in the Adjuvant Treatment of Pediatric Asthma Complicated with Allergic Rhinitis
摘要
Abstract
Objective To investigate the clinical efficacy of Dermatophagoides Farinae Drops combined with Vitamin D Drops in the adjuvant treatment of pediatric asthma complicated with allergic rhinitis.Methods A total of 112 children with asthma and allergic rhinitis admitted to the Xuzhou Children's Hospital from January 2019 to January 2021 were selected and divided into the control group and the observation group by the random number table method,with 56 cases in each group.The children in the two groups were given oral Loratadine Granules,on this basis,the children in the observation group were given Dermatophagoides Farinae Drops combined with Vitamin D Drops(capsules).Both groups were treated continuously for six months.Results The short-term total effective rate in the observation group was 73.21%,which was similar to 67.86%in the control group(P>0.05).The long-term total effective rate in the observation group was 91.07%,which was significantly higher than 71.43%in the control group groups significantly decreased;the lung function-related indexes[percentages of forced vital capacity(FVC),forced expiratory volume in one second(FEV1),peak expiratory flow(PEF),forced expiratory flow at 25%,50%and 75%of FVC(FEF25,FEF50,FEF75),maximum mid-expiratory flow(MMEF)to expected values]significantly increased;the sneezing,nasal itching scores,and lung function-related indexes in the observation group were significantly better after six months of treatment(P<0.05).After six months of treatment,the serum interleukin-4(IL-4),interleukin-5(IL-5),interleukin-12(IL-12)and tumor necrosis factor-α(TNF-α)levels were significantly lower than those in the control group(P<0.05).There was no serious adverse reaction in the two groups,and there was no abnormality in the blood and urine routine tests;only two children in the control group experienced discomfort in the throat,which relieved spontaneously after 3 d.Conclusion The adjuvant treatment of Dermatophagoides Farinae Drops combined with Vitamin D Drops can relieve the clinical symptoms and improve the lung function in children with asthma and allergic rhinitis.关键词
粉尘螨滴剂/维生素D滴剂/哮喘/过敏性鼻炎/症状评分/肺功能/临床疗效Key words
Dermatophagoides Farinae Drops/Vitamin D Drops/asthma/allergic rhinitis/symptom score/lung function/clinical efficacy分类
医药卫生引用本文复制引用
成晨,柳荫,赵淑玲,周钦..粉尘螨滴剂联合维生素D滴剂辅助治疗儿童哮喘伴过敏性鼻炎临床观察[J].中国药业,2024,33(16):116-119,4.基金项目
江苏省徐州市儿童医院科研项目[23040437]. （）
