中国药业2024，Vol.33Issue(16)：140-143,4.DOI:10.3969/j.issn.1006-4931.2024.16.033
低分子肝素钙联用哌拉西林钠他唑巴坦钠致重度血小板减少个案分析
Severe Thrombocytopenia Induced by Low Molecular Weight Heparin Calcium Combined with Piperacillin Sodium and Tazobactam Sodium:A Case Report
唐长征 1姚威 1唐莉 2李思光1
作者信息
- 1. 安徽省亳州市中医院,安徽 亳州 236800
- 2. 安徽省亳州市人民医院,安徽 亳州 236800
- 折叠
摘要
Abstract
Objective To provide a reference for the safe use of low molecular weight heparin calcium and piperacillin sodium and tazobactam sodium in clinical practice.Methods The treatment process of an elderly male patient with diabetes foot suffering from severe thrombocytopenia induced by low molecular weight heparin calcium combined with piperacillin sodium and tazobactam sodium admitted to the Bozhou Hospital of Traditional Chinese Medicine was analyzed retrospectively.Results The patient was admitted to the hospital due to the right foot ulceration for one month,with a high platelet count(PLT)of 571×109/L at admission.He was given Piperacillin Sodium and Tazobactam Sodium for Injection(4.5 g,intravenous drip,once every 8 h)and Low Molecular Weight Heparin Calcium Injection(4000 AⅩaIU,subcutaneous injection)based on urine bacterial culture and drug sensitivity test while receiving routine insulin to lower blood glucose.After 12 d of treatment,the patient's PLT decreased to 14×109/L(severe thrombocytopenia),which might be related to the combination of the above two drugs.After discontinuing the two drugs for 4 d,his PLT increased to 52×109/L,and returned to normal after 6 d.Conclusion When using low molecular weight heparin calcium combined with piperacillin sodium and tazobactam sodium in clinical practice,it should be considered that this may lead to severe thrombocytopenia.The patients'blood routine and clinical manifestations should be closely monitored,and the adverse drug reaction should be promptly treated.关键词
哌拉西林钠他唑巴坦钠/低分子肝素钙/联合用药/血小板减少/糖尿病足/用药安全/药学监护Key words
piperacillin sodium and tazobactam sodium/low molecular weight heparin calcium/combination medication/thrombocytopenia/diabetes foot/medication safety/pharmaceutical care分类
医药卫生引用本文复制引用
唐长征,姚威,唐莉,李思光..低分子肝素钙联用哌拉西林钠他唑巴坦钠致重度血小板减少个案分析[J].中国药业,2024,33(16):140-143,4.
