中华临床免疫和变态反应杂志2024，Vol.18Issue(4)：370-375,6.DOI:10.3969/j.issn.1673-8705.2024.04.007
变应原皮下注射免疫治疗致全身过敏反应的回顾性分析
Retrospective study on systemic allergic reactions induced by subcutaneous allergen-spe-cific immunotherapy
摘要
Abstract
Objective To analyze the clinical features of systemic allergic reactions induced by subcuta-neous allergen-specific immunotherapy(SCIT)retrospectively and to explore risk factors related to moderate to severe systemic allergic reactions.Methods A single-center retrospective study was designed.The medical re-cords of allergic rhinitis and/or asthma patients with SCIT-related immediate systemic allergic reactions were col-lected in Outpatient Clinic of Department of Allergy,Peking Union Medical College Hospital since 2012 to 2022.Demographic information,clinical diagnosis,formula and concentration of allergens extracts used in SCIT,clinical manifestations and treatment of systemic allergic reactions induced by SCIT and other information were summarized.Risk factors related to severity of systemic reactions were also investigated.Results A total of 59 pa-tients experienced 72 systemic allergic reactions caused by SCIT and 11 of them experienced multiple reactions since 2012 to 2022.14 of them were diagnosed as single allergic rhinitis(AR),6 as single asthma and another 39 as AR with asthma.According to World Allergy Organization(WAO)classification of severity,18 GradeⅠ,46 GradeⅡ,2 GradeⅢand 6 Grade Ⅳ reactions were recorded,whereas no fatal reaction occurred.Cutaneous symptoms occurred among 72.2%of patients,upper and lower respiratory symptoms among 70.8%and circulatory system symptoms among 16.7%of them.The average age of mild group(Grade I reaction)was 11(8,20)years-old,significantly younger than that of moderate and severe group(GradeⅡtoⅣreaction,P=0.032,which was 24(9,35)years-old.Conclusions Severity of systemic allergic reactions induced by SCIT was mainly mild to moderate among patient in this study,while cutaneous and respiratory allergic symptoms were the major clinical manifestations.Age might be a influencing factor related to severity of systemic reactions.关键词
免疫治疗/变应原/皮下注射免疫治疗/全身过敏反应/严重程度Key words
immunotherapy/allergens/subcutaneous allergen-specific immunotherapy/systemic allergic reaction/severity引用本文复制引用
王青,李宇,支凡,李丽莎,尹佳,王良录,支玉香,孙劲旅,关凯,刘君,郑杰..变应原皮下注射免疫治疗致全身过敏反应的回顾性分析[J].中华临床免疫和变态反应杂志,2024,18(4):370-375,6.基金项目
国家自然科学基金(82070033) （82070033）
北京市自然科学基金(7222136) （7222136）
中国医学科学院医学与健康科技创新工程项目(2021-I2M-1-017) （2021-I2M-1-017）
中央高水平医院临床科研业务费(2022-PUMCH-B-089) National Natural Science Foundation of China(82070033) （2022-PUMCH-B-089）
Natural Science Founda-tion of Beijing(7222136) （7222136）
Medical and Health Science and Technology Innovation Project of Chinese Acade-my of Medical Sciences(2021-I2M-1-017) （2021-I2M-1-017）
National High Level Hospital Clinical Research Funding(2022-PUMCH-B-089) （2022-PUMCH-B-089）
