中华临床免疫和变态反应杂志2024，Vol.18Issue(4)：394-400,7.DOI:10.3969/j.issn.1673-8705.2024.04.012
免疫相关不良反应:流行病学、临床表现及危险因素
Immune-relatedadverse events:epidemiology,clinical manifestations,and risk factors
摘要
Abstract
Immune checkpoint inhibitors(ICIs)represent a significant breakthrough in the field of on-cology in recent years,greatly improving treatment outcomes and prognosis for patients with various malignant tumors.However,with the increasing use of ICIs,the incidence of treatment-related adverse events has also risen.As immune-related adverse events(irAEs)can occur after treatment cessation or independently of disease progression,patients may present with symptoms affecting different systems,often initially seeking care from internists rather than oncologists.Consequently,internists are faced with heightened responsibilities to profi-ciently discern irAEs.This article provides a comprehensive review of the epidemiology,clinical manifestations,and various risk factors associated with representative irAEs in clinical practice,aiming to familiarize internists with diverse irAEs for effective management.关键词
免疫检查点抑制剂/免疫相关不良反应/内科Key words
immune checkpoint inhibitors/immune related adverse events/internal medicine引用本文复制引用
姚孟辉,张昀,曾学军..免疫相关不良反应:流行病学、临床表现及危险因素[J].中华临床免疫和变态反应杂志,2024,18(4):394-400,7.基金项目
国家自然科学基金(82071841) National Natural Science Foundation of China(82071841) （82071841）
