浙江医学2024，Vol.46Issue(15)：1607-1612,6.DOI:10.12056/j.issn.1006-2785.2024.46.15.2024-707
宫腔灌注粒细胞集落刺激因子对薄型子宫内膜患者冻融胚胎移植妊娠结局的影响
Effect of intrauterine perfusion of granulocyte-colony stimulating factor on pregnancy outcome of patients with thin endome-trium undergoing frozen-thawed embryo transfer
摘要
Abstract
Objective To investigate the effect of intrauterine perfusion with granulocyte colony-stimulating factor(G-CSF)on pregnancy outcomes in women with thin endometrium undergoing frozen-thawed embryo transfer(FET).Methods In this retrospective cohort study,132 women with thin endometrium undergoing frozen-thawed embryo transfer cycles in Reproductive Medicine Center of Huzhou Maternity & Child Health Care Hospital from January 2017 to October 2023 were enrolled,including 76 cases receiving intrauterine infusion of G-CSF before the day of administration of pro-gesterone(G-CSF group),and 56 patients without G-CSF treatment(control group).The general data of patients and pregnancy outcome of FET were compared between the two groups;endometrial thickness was compared before and after intrauterine perfusion;and multivariate modified Poisson regression was used to analyze the influencing factors of clinical pregnancy.Results In G-CSF group,the endometrial thickness was significantly increased from(5.4±0.9)mm to(7.6±0.9)mm(P＜0.05)after G-CSF perfusion.The embryo implantation rate and clinical pregnancy rate in the G-CSF group were significantly higher than those in the control group(40.0％vs.30.3％,52.6％vs.33.9％,both P＜0.05);and the early miscarriage rate was on a downward trend,but there was no statistical difference between the two groups(25.0％vs.31.6％,P＞0.05).Multivariate modified Poisson regression analysis suggested that the intrauterine perfusion of G-CSF had no significant impact on clinical pregnancy rate after adjusting confounding factors(RR=1.217,95％CI:0.615-2.410,P＞0.05).Conclusion In patients with thin endometrium,intrauterine perfusion of G-CSF can be considered to increase the end-ometrium thickness for FET to improve the clinical pregnancy rate and implantation rate.关键词
粒细胞集落刺激因子/薄型子宫内膜/临床妊娠率/胚胎种植率/早期流产率Key words
Granulocyte colony stimulating factor/Thin endometrium/Clinical pregnancy rate/Embryo implantation rate/Early miscarriage rate引用本文复制引用
陈丽芬,周媛萍,董其音,曹单..宫腔灌注粒细胞集落刺激因子对薄型子宫内膜患者冻融胚胎移植妊娠结局的影响[J].浙江医学,2024,46(15):1607-1612,6.基金项目
湖州市科学技术局公益性应用研究项目(2023GYB36、2021GYB28) （2023GYB36、2021GYB28）
