浙江医学2024，Vol.46Issue(15)：1625-1631,7.DOI:10.12056/j.issn.1006-2785.2024.46.15.2023-1804
超声结节-肌肉灰阶比值对甲状腺结节良恶性的预测价值研究
Value of nomogram model based on ultrasonographic parameters in differentiating benign and malignant thyroid nodules
摘要
Abstract
Objective To investigate the value of nomogram model based on ultrasonographic parameters in differentiating benign and malignant thyroid nodules.Methods A total of 152 patients with thyroid nodules admitted in Yuhang District Third People's Hospital and Hangzhou First People's Hospital from May 2020 to December 2022 were included in the study.Adobe Photoshop CS6 software was used to measure the gray scale values of thyroid nodules,thyroid tissue and muscle tissue on ultrasonographic images,and the ultrasonic gray scale ratios were calculated.Multivariate logistic regression was used to analyze the influencing factors of benign and malignant nodules,based on which a nomogram model was developed to differentiate benign and malignant thyroid nodules,and ROC curve was used to analyze its differentiating efficiency.Results A total of 157 thyroid nodules were detected in 152 patients,including 77 benign nodules and 80 malignant ones.Multivariate logistic regression analysis showed that the maximum diameter(OR=0.823,95％CI:0.734-0.923)and nodule-muscle gray scale ratio(OR=0.207,95％CI:0.057-0.749),edge case(OR=0.298,95％CI:0.130-0.682),aspect ratio(OR=0.177,95％CI:0.071-0.441)were independent factors influencing factors of benign and malignant thyroid nodules(all P＜0.05).Incorporating these four ultrasonic features,a nomogram model was generated to differentiate benign and malignant thyroid nodules.The area under ROC curve(AUC)of the model in differentiating benign and malignant thyroid nodules was 0.845(95％CI:0.783-0.907),and the sensitivity and specificity were 0.787 and 0.844,respectively,and the accuracy was 0.815,when the Yodon index was the highest.Conclusion The nomogram model based on the ratio of ultrasonic nodule to muscle gray scale,the maximum diameter of the nodule,the aspect ratio and the edge of the nodule has a good prediction effect in differentiating the benign and malignant thyroid nodules.关键词
灰阶比值/甲状腺结节/列线图Key words
Gray scale ratio/Thyroid nodules/Nomogram引用本文复制引用
马美萍,张煜,潘钢,章永萍,陈友法,李丙锋,魏晓建,王海,林勇强..超声结节-肌肉灰阶比值对甲状腺结节良恶性的预测价值研究[J].浙江医学,2024,46(15):1625-1631,7.基金项目
浙江省医药卫生科技计划项目(2023KY179) （2023KY179）
浙江省基础公益研究计划项目(LGF22H160047) （LGF22H160047）
